Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2018-A03511-54 | Other Identifier | ANSM |
Not provided
Not provided
Due to the health crisis and the lack of staff in the department no inclusion could be realized
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| University of Saint-Etienne | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This chronic fatigue affects their quality of life by decreasing their capacity to perform simple tasks of daily life.
The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in this feeling of chronic fatigue. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology will allow to optimize rehabilitation treatments to decrease the apparition/persistence of chronic fatigue and in fine improve life quality.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| "Non-fatigued" patients | Experimental |
| |
| "Fatigued" patients | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Questionnaires | Other | Quality of life Depression Physical pain Social provisions Quality of sleep |
|
| Measure | Description | Time Frame |
|---|---|---|
| voluntary maximum force reduction | at 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Neuromuscular function : cortical activity | Level of cortical activation and cortico-spinal excitability measured by transcranial magnetic stimulation | at 2 weeks |
| Neuromuscular function : Peripheral function |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Jérome MOREL, MD PhD | CHU de Saint Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital privé de la Loire | Saint-Etienne | 42000 | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| blood test | Biological | complete blood count and cytokine concentration |
|
| Maximal effort test | Other | The maximal effort test with VO2max recordings will be assessed during the first visit to the laboratory. |
|
| actigraphy | Device | assessment of sleep quality |
|
| Neuromuscular evaluation | Device |
|
|
Peripheral function by electrical nerve stimulation
| at visit 2 |
| Maximal oxygen uptake (VO2max) | measured by effort test | at 2 weeks |
| quality of sleep | measured by actigraphy | at baseline |
| Quadriceps muscle volume (optional) | with Magnetic resonance imaging | at 3 weeks |
| muscle dysfunction (optional) | measured by a Phosphorus 31 Nuclear magnetic resonance test | at 3 weeks |
| ID | Term |
|---|---|
| D015673 | Fatigue Syndrome, Chronic |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D004679 | Encephalomyelitis |
| D000090862 | Neuroinflammatory Diseases |
| D009422 | Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| D006403 | Hematologic Tests |
| D056044 | Actigraphy |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008991 | Monitoring, Physiologic |
| D061725 | Accelerometry |
Not provided
Not provided