GA 6: The Blood Glucose-lowering Effect of Glucose-dependent Insulinotropic Polypeptide

The Blood Glucose-lowering Effect of Glucose-dependent Insulinotropic Polypeptide

This study will investigate if the effect of DPP-4 inhibitors is mediated in part by Glucose-dependent insulinotropic polypeptide.

A randomized, placebo controlled study. Using a GIP receptor antagonist, we will investigate the glucose lowering effect of GIP during treatment with DPP-4 inhibitors.

Inclusion Criteria:

• type 2 diabetes, treatment: lifestyle changes or metformin
• HbA1c < 75 mmol/mol

Exclusion Criteria:

• diagnosed liver disease
• eGFR < 60 ml/min/1,73m2
• NYHA III or IV
• anemia.