Not provided
Not provided
Not provided
Not provided
Hard to recruit due to COVID-19 issue.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Seoul National University Bundang Hospital | OTHER |
Not provided
Not provided
Not provided
Not provided
Numerous elderly patients are suffering from aspiration pneumonia due to anatomical or functional predisposing factors including enteral tube feeding, swallowing difficulties, and gastroesophageal reflux disease (GERD). Previous studies have been demonstrated that continuous positive airway pressure (CPAP) is an acceptable means of managing chronic aspiration, atelectasis, and GERD. The purpose of this study is to determine whether nocturnal nasal CPAP is beneficial in patients with aspiration pneumonia and that it would contribute to the rapid clinical stability of aspiration pneumonia.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| nasal CPAP group | Experimental | Applying nocturnal nasal continuous positive airway pressure in additional to usual pneumonia treatment |
|
| Control group | No Intervention | Usual pneumonia treatment |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nocturnal nasal continuous positive airway pressure | Device | applying nasal continuous positive airway pressure at 7.5-10cmH2O for at least 4 hours during nighttime |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to clinical stability-respiration (CS-r) | time to respiratory stabilization (respiratory rate ≤ 24/min and arterial oxygen saturation ≥ 90% or a partial pressure of oxygen ≥ 60mmHg on room air or usual requirement level) | up to 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Time to clinical stability | time to clinical stabilization | up to 2 weeks |
| Early clinical stability rate | day 3 clinical stability rate |
Not provided
Inclusion Criteria:
Age ≥ 65 years
Diagnosis of pneumonia: the presence of new pulmonary infiltration in dependent areas on chest radiographs at the time of hospitalization with at least one of the following
Aspiration tendency or risk factors for frequent or large volume aspiration with at least one of the following
Informed consent
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Eun Sun Kim, MD | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | South Korea |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D011015 | Pneumonia, Aspiration |
| C564247 | Microcephaly, Primary Autosomal Recessive, 6 |
| ID | Term |
|---|---|
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D008171 | Lung Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| 3 days |
| Late clinical stability rate | day 7 clinical stability rate | 7 days |
| Hospital length of stay | length of hospital admission | 1 day (during hospital admission) |
| Radiological improvement | improvement of lung infiltration or atelectasis | 3 and 7 days |
| Broadening of antimicrobial spectrum | escalation antibiotics | 1 day (during hospital admission) |
| Frequency of bronchoscopy for toileting | frequency of invasive lung care like bronchoscopy | 1 day (during hospital admission) |
| In-hospital mortality | all cause mortality | 1 day (during hospital admission) |
| D012140 |
| Respiratory Tract Diseases |