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| Name | Class |
|---|---|
| The Norwegian Resouce Centre for Cystic Fibrosis | UNKNOWN |
| Norwegian National Adivisory Unit on Rare Disorders | OTHER |
| University Hospital, Akershus | OTHER |
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Due to the hypobaric hypoxia during air travel, some patients with Cystic Fibrosis (CF) need supplemental oxygen during air travel.
The study aims to evaluate if adding exercise desaturation to the pre-flight evaluation will help predict requirements for in-flight supplemental oxygen.
According to the British Thoracic Society (BTS) recommendations regarding pre-flight evaluation in patients with pulmonary disease, pre-flight arterial oxygen saturation or lung function tests do not discriminate sufficiently between those who need supplemental oxygen during flights, and those who can do without.Therefore, more extensively use of Hypoxia Altitude Simulation test (HAST) has been advocated. However, this test is not widely available. Previous studies have shown that exercise testing is useful for the prediction of in-flight hypoxemia. The investigators have previously developed a pre-flight algorithm for patients with chronic obstructive pulmonary disease (COPD), based on oxygen saturation measured by pulse oximetry at rest and during exercise (six minute walking test (6MWT)). It remains unknown as to whether these results are applicable to the CF population.
The current study aims to validate the pre-flight algorithm for patients with CF. Since a maximum cardiopulmonary exercise test (CPET) is recommended in the routine CF-control, the investigators also aim to evaluate whether the use of CPET predicts in-flight hypoxemia with greater accuracy than 6MWT, and whether CPET may replace HAST.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pre-flight evaluation | Other | All the participants receive the interventions as part of their routine medical care during their annual visit for CF follow-up. Oxygen saturation are measured by pulse oximetry. Exercise testing is performed by 6MWT and CPET. Pre-flight evaluation is performed by HAST. |
| Measure | Description | Time Frame |
|---|---|---|
| Does oxygen saturation during exercise predict in-flight hypoxemia in adult patients with CF? | Oxygen saturation is measured by pulse oximetry (SpO2) during exercise and HAST | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with CF evaluated at the Norwegian Resource Centre for Cystic Fibrosis at the Dep. of Pulm. Med. Oslo University Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Aina Akerø, MD PhD | Oslo University Hospital, Dept. of Pulm. Med. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital Ullevaal, Department of Pulmonary Medicine | Oslo | 0407 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22767877 | Background | Edvardsen A, Akero A, Christensen CC, Ryg M, Skjonsberg OH. Air travel and chronic obstructive pulmonary disease: a new algorithm for pre-flight evaluation. Thorax. 2012 Nov;67(11):964-9. doi: 10.1136/thoraxjnl-2012-201855. Epub 2012 Jul 5. | |
| 21856702 | Background | Ahmedzai S, Balfour-Lynn IM, Bewick T, Buchdahl R, Coker RK, Cummin AR, Gradwell DP, Howard L, Innes JA, Johnson AO, Lim E, Lim WS, McKinlay KP, Partridge MR, Popplestone M, Pozniak A, Robson A, Shovlin CL, Shrikrishna D, Simonds A, Tait P, Thomas M; British Thoracic Society Standards of Care Committee. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax. 2011 Sep;66 Suppl 1:i1-30. doi: 10.1136/thoraxjnl-2011-200295. No abstract available. |
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There is no plan to make individual participants data available to other researchers due to restrictions from Oslo University Hospital
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| D000860 | Hypoxia |
| D008171 | Lung Diseases |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D012140 | Respiratory Tract Diseases |
| D030342 | Genetic Diseases, Inborn |
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| 40467430 | Derived | Akero A, Edvardsen E, Finstad PL, Skrede B, Osterhaug M, Backman S, Edvardsen A, Skjonsberg OH. Air travel and cystic fibrosis: An algorithm to assess the risk of In-Flight Hypoxemia. J Cyst Fibros. 2025 Sep;24(5):963-969. doi: 10.1016/j.jcf.2025.05.004. Epub 2025 Jun 3. |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |