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Research project in which patients with Multiple Sclerosis (MS) are examined clinically and with magnetic resonance imaging (MRI). To evaluate spinal cord (SC) grey and white matter changes (incl. lesions) using fast, high-resolution MRI sequences with high contrast between SC and cerebrospinal fluid (CSF) as well as high contrast within the SC (grey-white matter contrast).
The Swiss Multiple Sclerosis Cohort (SMSC-Study) aims to better evaluate specific Multiple Sclerosis (MS) phenotypes through the systematic and standardised documentation and acquisition of clinical course and paraclinical tests such as magnetic resonance imaging (MRI), blood and cerebrospinal fluid (CSF) specimens.
Determination of the relative contribution of SC metrics (cervical cord volume, cervical grey matter (GM) cord volume, cervical white matter (WM) cord volume, SC lesion load) to disability in MS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| relapsing-remitting MS undergoing spinal cord MRI |
| ||
| secondary progressive MS undergoing spinal cord MRI |
| ||
| primary progressive MS undergoing spinal cord MRI |
| ||
| healthy control (HC) undergoing spinal cord MRI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| spinal cord MRI | Diagnostic Test | high-resolution spinal cord MRI sequences on a 3Tesla magnet (Siemens Prisma) with high contrast between SC and CSF as well as high contrast within the SC (grey-white matter contrast) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in SC atrophy assessed by MRI | Determination of the degree of SC grey and white matter atrophy in MS patients with relapsing versus progressive disease courses in comparison to matched HC. Measurement tool is a structural MRI of the brain and spinal cord at 3 Tesla. Assessment will last approx. 90 minutes. | at baseline and after 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Timed 25-foot walk test (T25-FW) | Quantitative mobility and leg function performance test ( in MS patients) based on a timed 25-walk. The patient is directed to one end of a clearly marked 25-foot course and is instructed to walk 25 feet as quickly as possible, but safely. The time is calculated from the initiation of the instruction to start and ends when the patient has reached the 25-foot mark. |
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Inclusion criteria
Exclusion Criteria for all participants:
History of severe (other) neurological, internistic or psychiatric disease
MRI related exclusion criteria:
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The recruitment of MS patients will take place within the ongoing SMSC study at the MS Clinic of the Department of Neurology (Neurologische Klinik und Poliklinik), University Hospital Basel (Universitätsspital Basel). Healthy subjects will be recruited by public announcements on the University Hospital's and the University's notice board.
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| Name | Affiliation | Role |
|---|---|---|
| Ludwig Kappos, Prof. Dr. MD | Department of Neurology University Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dep. of Neurology, University Hospital Basel | Basel | 4031 | Switzerland |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| at baseline and after 1 year and after 5 years |
| Change in Multiple Sclerosis Walking Scale-12 (MSWS-12) Questionnaire | Self-assessment scale which measures the impact of MS on walking. It consists of 12 questions concerning the limitations to walking due to MS during the past 2 weeks. Each item can be answered with 5 options, with 1 meaning no limitation and 5 extreme limitation. | at baseline and after 1 year and after 5 years |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |