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| Name | Class |
|---|---|
| Egg Nutrition Center | OTHER |
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Purpose: To establish a whole food, egg, as a viable study material to supplement mothers and infants with nutrients that support optimal brain development. There will be 84 breastfeeding dyads, 3 months postnatal.
Mothers will be randomized to a whole egg or egg white (due to lack of an appropriate control food). Initial diet intake will be screened using the NDSR. Participants will come to the lab 3 times across 3 months (age 3 months, 4.5 months, and 6 months). Milk, saliva, and plasma will be collected from the mother, while saliva and plasma (heel stick) are collected from the infant. Diet data will be collected at each visit. The infant will complete a recognition memory test using electrophysiology at 6 months as well as the Bayley Scales of Infant Development at 4.5 months. The mother will complete a temperament questionnaire at 3 months and 6 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Whole egg powder | Experimental | Participants are given whole egg powder which contains high levels of the nutrients choline, lutein, and docosahexaenoic acid. |
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| Egg white powder | Placebo Comparator | The participants are given an egg white powder that does not contain the target nutrients (choline, lutein, and docosahexaenoic acid). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whole Egg Powder | Dietary Supplement | Breastfeeding mothers will consume the equivalent of 5 whole eggs per week for 3 months. |
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| Measure | Description | Time Frame |
|---|---|---|
| Recognition Memory in an Oddball Task | The difference in microvolts between the negative deflection to novel pictures and the negative deflection to familiar pictures at approximately 100-400ms after the pictures come on the screen will be measured in an event-related potentials (ERP) paradigm. The investigators hypothesize that the whole egg group will have better memory for the familiar pictures than the egg white group. | 13 weeks (at 6 months of age) |
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| Measure | Description | Time Frame |
|---|---|---|
| Bayley Scales of Infant Development (BSID) | BSID administered at 4.5 months | 6 weeks (at 4.5 months of age) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carol L Cheatham, PhD | Contact | 704-250-5010 | carol_cheatham@unc.edu | |
| Study Coordinator | Contact | 704-250-5018 | feedingbrains@unc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Carol L Cheatham, Ph.D. | Associate Professor, University of North Carolina-Chapel Hill | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nutrition Research Institute | Recruiting | Kannapolis | North Carolina | 28081 | United States |
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| ID | Term |
|---|---|
| D001942 | Breast Feeding |
| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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Participants will be randomized to whole egg or egg white powder to consume throughout the study.
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The participants will be given a jar of egg powder without labeling and they will not be aware of which they receive (egg white or whole egg).
| Egg White Powder | Dietary Supplement | Breastfeeding mothers will consume the equivalent of 5 egg whites per week for 3 months. |
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