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The current study aims to assess the effect of assisted hatching on the implantation rate of frozen blastocytes.
The Zona Pellucida protects the ovum from the penetration of multiple sperm, and from mechanical and physiological damage until the fertilized ovum reaches the uterus. Subsequently, spontaneous hatching occurs, and enables the embryo to attach to the endometrium. The technique of assisted hatching was originally investigated as a means to improve implantation in cases of zona hardening, and is commonly performed in 3-day embryos. In the current study, the investigators aim to investigate the effect of assisted hatching on 5-day frozen embryos.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Assisted hatching | Experimental | Five-day frozen embryos will undergo assisted hatching prior to embryo transfer |
|
| Control | No Intervention | Five-day frozen embryos will not undergo any additional procedures prior to embryo transfer |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Assisted hatching | Procedure | Controlled hatching of the zona pellucida in the laboratory prior to embryo transfer |
|
| Measure | Description | Time Frame |
|---|---|---|
| Implantation rate | Number of gestational sacs demonstrated on ultrasound divided by the number of embryos transferred (expressed as percentage) | Five to six weeks following embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| Chemical pregnancy | Increase and subsequent decrease in beta HCG levels with no evidence of gestational sac on ultrasound | Five to six weeks following embryo transfer |
| Early spontaneous abortion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hadas Ganer Herman, MD | Contact | 9720526206696 | hadassganer@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Hadas Ganer Herman, MD | Edith Wolfson Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Edith Wolfson Medical Center | Recruiting | Holon | Israel |
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Spontaneous abortion of pregnancy during the first trimester of pregnancy
| Up to 15 weeks from embryo transfer |