The researchers are trying to develop a way to measure the risk of transplant rejection with a blood test.

The study will utilize peripheral blood assays collected at time points that are considered standard of care at most institutions. Subjects will have peripheral blood collected at 1 month, 3 months, 6 months, and 12 months after heart transplantation, as well as any for cause time points. These samples will then be used for purposes of developing an RNA-seq based peripheral blood assay in adult heart transplant recipients.

Inclusion Criteria:

Patients who meet all of the following criteria are eligible for enrollment as study participants:

• Adult (≥18 years) solitary heart transplant recipient
• Patient is willing and able to provide informed written consent

Exclusion Criteria:

Patients who meet any of these criteria are not eligible for enrollment as study participants:

• Adult (<18 years) heart transplant recipient
• Patient refusal to enroll in the studyc3. Any simultaneous heart and extra organ transplant, including pancreas, liver, lung, kidney, etc. Subjects who have had previous transplants may be included.

Heart Transplant recipients