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| Name | Class |
|---|---|
| Juvenile Diabetes Research Foundation | OTHER |
| Colorado Clinical & Translational Sciences Institute | OTHER |
| Ludeman Family Center for Women's Health Research | UNKNOWN |
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Despite advancements in care, most adolescents with T1D have higher BMI and significantly higher HbA1c than recommended and are markedly IR, placing them at increased risk for CVD1,2. Thus, alternative approaches to improve and maintain glycemic control, IR, and BMI for adolescents with T1D are urgently needed. This proposal moves beyond the current insulin and carbohydrate counting-focused lifestyle change paradigm to focus on sleep and circadian misalignment, which will allow for identification of new mechanisms that can be directly translated into future intervention and prevention trials. The goal of the current study is to utilize multiple objective measures of sleep duration, timing (actigraphy), and circadian rhythm (melatonin) in adolescents with type 1 diabetes (T1D; N = 40) and examine relationships with glycemic control, IR, vascular health, and BMI. Further, qualitative methodology will be used to identify barriers and facilitators to healthy sleep in adolescents with T1D.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| adolescents with type 1 diabetes | Adolescents ages 14-19 with type 1 diabetes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| observation | Other | observation |
|
| Measure | Description | Time Frame |
|---|---|---|
| HbA1c | HbA1c | at 60 days |
| glycemic variability | CGM glucose SD | at 2 weeks |
| insulin sensitivity from hyperinsulinemic euglycemic clamp | Si | at study entry (baseline) |
| BMI | body mass index | at study entry (baseline) |
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Inclusion Criteria:
Exclusion Criteria:
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Adolescents with type 1 diabetes
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Anschutz Medical Campus/Children's Hospital Colorado | Aurora | Colorado | 80045 | United States |
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| ID | Term |
|---|---|
| D000294 | Adolescent Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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