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The aim of this study is to compare the effects of Ivabradine and metoprolol to reduce heart rate prior to coronary CT angiography in patients with advanced heart failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ivabradine | Active Comparator |
| |
| metoprolol | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ivabradine | Drug | 7.5 mg oral single dose if the heart rate would not reach to 60/minute then give another dose, 7.5 mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | Changing heart rate during imaging study | 30 minutes before and after coronary CT angiography |
| Measure | Description | Time Frame |
|---|---|---|
| Dyspnea | Shortness of breath, or "dyspnea", is the most famous symptom of left ventricular failure. It typically appears during strenuous activities, and progresses to ordinary activities, less than ordinary activities and ultimately resting state. The severity is categorized as above (FC 1 to 4) | 30 minutes before and after coronary CT angiography and 6 months later |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ahmad Amin | Recruiting | Tehran | 1996911151 | Iran |
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| Metoprolol | Drug | 5 mg oral single dose if the heart rate would not reach to 60/minute then give another dose, 5 mg |
|
| Functional calss | Heart Failure severity has been classified according to New York Heart Association (NYHA) to:
| 30 minutes before and after coronary CT angiography and 6 months later |
| Blood pressure, systolic and diastolic | The amount of blood pressure measured by sphygmomanometer | 30 minutes before and after coronary CT angiography and 6 months later |
| Sleep quality | The rate of disturbed sleep measured as better than before, Worse than before, and No change There are no standard classification for severity of this symptom. In our study, we measure this symptom as :
| Before CT angiography and 6 months later |
| Appetite | The rate of changing in appetite level measured as better than before, Worse than before, and No change Loss of appetite is a common symptom of heart failure. There are no standard classification for severity of this symptom. In our study, we measure this symptom as :
| Before CT angiography and 6 months later |
| Prolonged bradycardia | Persistence of Bradycardia more than 6 hours is called prolonged bradycardia. | 30 minutes before and after coronary CT angiography |
| Hypotension | Systolic less than 80 mm Hg | 30 minutes before and after coronary CT angiography |
| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D054143 | Heart Failure, Systolic |
| D054144 | Heart Failure, Diastolic |
| D001919 | Bradycardia |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001145 | Arrhythmias, Cardiac |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077550 | Ivabradine |
| D008790 | Metoprolol |
| ID | Term |
|---|---|
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
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