Misoprostol is a synthetic analogue of the naturally occurring prostaglandin E1. It was initially marketed for the treatment of peptic ulcers due to its mucosal protective and anti-secretory properties, but has commonly been used for the induction of abortion and labour .

Although initially having been established for oral use, misoprostol tablets are commonly used as vaginal suppositories for the previously purposes. Water or saline are frequently used in common practice to moisten the tablets prior to their administration, however, according to the pharmacokinetics of the drug, it should liquefy better in an acidic medium

Inclusion Criteria:

• Singleton pregnancies. Gestational age 38-41 weeks. Cephalic presentation

Exclusion Criteria:

• 1. Multi-fetal pregnancy. 2. Pregnant women less than 38 weeks gestation.

Full term pregnant women