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This study was conducted to investigate the effects of daily supplementation of Red Ginseng Concentrated Powder on Improvement of Blood Triglyceride Level.
This study was a 12-week, randomized, double-blind, placebo-controlled 2x2 cross-over design human trial. 50 subjects which of 25 by group were randomly divided into Red Ginseng Concentrated Powder and a placebo group.(A total of 100 subjects completed the 2x2 cross-over study.)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group A | Experimental | Red Ginseng Concentrated Powder in 12 weeks → rest in 4 weeks → Placebo 12 weeks.
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| group B | Experimental | Placebo 12 weeks→ rest in 4 weeks → Red Ginseng Concentrated Powder in 12 weeks.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Red Ginseng Concentrated Powder | Dietary Supplement | Red Ginseng Concentrated Powder(4.9 g/day) for 12 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Fasting triglyceride | Changes of Fasting triglyceride was assessed before and after the intervention | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Lipid metabolism indices | Lipid metabolism indices were assessed before and after the intervention. The lipid metabolism index should be measured by collecting blood while keeping fasting for 12 hours or more. The inspection items are as follows.
|
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Inclusion Criteria:
Exclusion Criteria:
Lipid lowering agent within past 6 months
Those with clinically significant severe cardiovascular, endocrine, immune, respiratory, liver, biliary, renal and urinary tract, neuropsychiatry, musculoskeletal, inflammatory and hematologic and gastrointestinal disorders
Persons with significant hypersensitivity reactions to ginseng and red ginseng
Those with a history of gastrointestinal disorders (ex, Crohn's disease) or gastrointestinal surgery (excluding simple cecal surgery or hernia surgery) that may affect the absorption of a product for clinical trials
Those who have received antipsychotic medication within 2 months before screening
Those with a history of alcoholism or substance abuse
Those who participated in other clinical trials within 2 months before screening
Laboratory test by show the following results
Pregnancy or breast feeding
Those who doesn't accept the implementation of appropriate contraception of a childbearing woman
Principal Investigator judged inappropriate for participation in study because of Laboratory test result, etc.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Trial Center for Functional Foods Chonbuk National University Hospital | Jeonju | Jeollabuk-do | 54907 | South Korea |
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| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Placebo | Dietary Supplement | Placebo for 12 weeks. |
|
| 30 weeks |
| Changes of Arteriosclerosis indices | It is calculated by the calculation formula using the lipid metabolism indicator test item. Round off the third decimal place to the second decimal place. The items are as follows: * Total cholesterol/HDL-C, LDL-C/HDL-C, triglycerid/HDL-C, (Total cholesterol - HDL-C)/HDL-C, Apo B/Apo A1 | 30 weeks |
| Changes of Carnitine (Serum) | Carnitine (Serum)[μmol/L] was assessed before and after the intervention. | 30 weeks |
| Changes of lipoprotein lipase | lipoprotein lipase[ng/ml] was assessed before and after the intervention | 30 weeks |