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Evidence supports the fact that multicomponent exercise and β-hydroxy-β-methylbutyrate (HMB) supplementation are, separately, effective in improving old adult's health and palliate functional metabolic diseases in the elderly. However, the true effect of HMB supplementation combined with a tailored exercise program in frail old adults is still unknown. Thus, the aim of the HEAL study is to assess the effects of the combination of a daily multicomponent exercise and resistance training intervention in addition to HMB supplementation on old adults' health.
Evidence supports the fact that multicomponent exercise and β-hydroxy-β-methylbutyrate (HMB) supplementation are, separately, effective in improving old adult's health and palliate functional metabolic diseases in the elderly. However, the true effect of HMB supplementation combined with a tailored exercise program in frail old adults is still unknown.
Thus, the aim of the HEAL study is to assess the effects of the combination of a daily multicomponent exercise and resistance training intervention in addition to HMB supplementation on old adults' health.
The findings of the HEAL study will help professionals from public health systems to identify cost-effectiveness and innovative actions to improve older people's health and quality of life, and endorse exercise practice in older adults living in nursing homes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ex-HMB | Experimental | HMB dietary supplementation and Multicomponent physical exercise program |
|
| NoEx-HMB | Experimental | HMB Dietary supplementation |
|
| Ex-Plac | Placebo Comparator | Multicomponent physical exercise program |
|
| Controls | No Intervention | No intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HMB dietary supplementation | Dietary Supplement | Intervention groups including HMB supplementation (Ex-HMB and NoEx-HMB) will receive a 3 g daily dose of free acid HMB in powder form dissolved freely into 250 mL of water during a 24-week intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in physical functional performance based on the Short Physical Performance Battery (SPPB) score | Summary scores range from 0-12 and higher scores denote higher physical performance. | Baseline to 25 Weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Handgrip strength (kg) | Using a dynamometer | Baseline to 25 Weeks |
| Change in lower-body strength (kg) | Seated leg press one-repetition maximun test |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Sport Sciences | Murcia | San Javier | 30720 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31277595 | Derived | Courel-Ibanez J, Pallares JG; HEAL study group. Effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in addition to multicomponent exercise in adults older than 70 years living in nursing homes, a cluster randomized placebo-controlled trial: the HEAL study protocol. BMC Geriatr. 2019 Jul 5;19(1):188. doi: 10.1186/s12877-019-1200-5. |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| Multicomponent physical exercise program | Other | Intervention groups including exercise (Ex-HMB and Ex-Plac) will complete an individualized multicomponent training program, five days a week during 24 weeks. |
|
| Baseline to 25 Weeks |
| Change in upper-body strength (kg) | Vertical bench press one-repetition maximun test | Baseline to 25 Weeks |
| Change in lower-body strength power output (m/s) | Seated leg press load-velocity profile | Baseline to 25 Weeks |
| Change in upper-body strength power output (m/s) | Vertical bench press load-velocity profile | Baseline to 25 Weeks |
| Change in frailty (score) | Frailty phenotype determination using Fried's criteria | Baseline to 25 Weeks |
| Change in lean body mass (kg) | Change in lean body mass using dual energy x-ray absorptiometry | Baseline to Week 25 |
| Change in lipid profile | Plasma total, high-density lipoprotein and low-density lipoprotein cholesterol and triglycerides (all in mg/dL) | Baseline to Week 25 |
| Change in glycaemic profile | Plasma glucose, insulin and glycosylated haemoglobin (all in mg/dL) | Baseline to Week 25 |
| Change in Thyroid-Stimulating Hormone (mIU/L) | Baseline to Week 25 |
| Change in Disability (Lawton index scores) | Disability in instrumental activities of daily living. | Baseline to 25 Weeks |
| Change in Disability (Barthel index scores) | Disability in basic activities of daily living | Baseline to 25 Weeks |
| Change in Comorbidity (score) | When a participant presents two or more geriatric syndromes from a list of selected geriatric syndromes | Baseline to 25 Weeks |
| Change in cognitive function (score) | Using the Mini-Mental State Examination | Baseline to 25 Weeks |
| Change in depression (score) | Using the 15-item Yesavage geriatric depression | Baseline to 25 Weeks |