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| ID | Type | Description | Link |
|---|---|---|---|
| 266/16 | Other Identifier | Local Ethics Committee of Modena (Italy) |
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This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive respiratory support failure in patients with acute hypoxic respiratory failure of different etiology (including COVID-19).
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| Measure | Description | Time Frame |
|---|---|---|
| Esophageal pressure impact on non invasive respiratory support (NRS) failure | Correlation between esophageal pressure values within 24 hours from NRS start and NRS failure | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Transpulmonary pressure impact on NRS failure | Correlation between transpulmonary pressure values within 24 hours from NRS start and NRS failure | 24 hours |
| Dynamic compliance impact on NRS failure |
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Inclusion Criteria:
Exclusion Criteria:
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See inclusion criteria
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alessandro Marchioni, MD, PhD | Contact | 00390594225859 | marchioni.alessandro@unimore.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Modena Policlinico | Recruiting | Modena | 41125 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38158462 | Derived | Tonelli R, Fantini R, Bruzzi G, Tabbi L, Cortegiani A, Crimi C, Pisani L, Moretti A, Guidotti F, Rizzato S, Puggioni D, Vermi M, Tacconi M, Bellesia G, Ragnoli B, Castaniere I, Marchioni A, Clini E. Effect of high flow nasal oxygen on inspiratory effort of patients with acute hypoxic respiratory failure and do not intubate orders. Intern Emerg Med. 2024 Mar;19(2):333-342. doi: 10.1007/s11739-023-03471-w. Epub 2023 Dec 29. | |
| 35331323 |
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Correlation between dynamic compliance values within 24 hours from NRS start and NRS failure
| 24 hours |
| Dynamic mechanical power impact on NRS failure | Correlation between dynamic mechanical power within 24 hours from NRS start and NRS failure | 24 hours |
| Correlation between nasal pressure (Pnose) and esophageal pressure | Correlation between nasal pressure (Pnose) and esophageal pressure | 24 hours |
| Pnose impact on NRS failure | Correlation between Pnose within 24 hours from NRS start and NRS failure | 24 hours |
| Derived |
| Tonelli R, Cortegiani A, Marchioni A, Fantini R, Tabbi L, Castaniere I, Biagioni E, Busani S, Nani C, Cerbone C, Vermi M, Gozzi F, Bruzzi G, Manicardi L, Pellegrino MR, Beghe B, Girardis M, Pelosi P, Gregoretti C, Ball L, Clini E. Nasal pressure swings as the measure of inspiratory effort in spontaneously breathing patients with de novo acute respiratory failure. Crit Care. 2022 Mar 24;26(1):70. doi: 10.1186/s13054-022-03938-w. |
| 32325004 | Derived | Tonelli R, Fantini R, Tabbi L, Castaniere I, Pisani L, Pellegrino MR, Della Casa G, D'Amico R, Girardis M, Nava S, Clini EM, Marchioni A. Early Inspiratory Effort Assessment by Esophageal Manometry Predicts Noninvasive Ventilation Outcome in De Novo Respiratory Failure. A Pilot Study. Am J Respir Crit Care Med. 2020 Aug 15;202(4):558-567. doi: 10.1164/rccm.201912-2512OC. |