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| Name | Class |
|---|---|
| Brain & Behavior Research Foundation | OTHER |
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This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.
Obsessive-compulsive disorder (OCD) is a chronic and disabling disorder characterized by recurrent intrusive thoughts and associated compulsive behaviors that is estimated to affect more than 3 million individuals in the US each year.
This study seeks to explore whether a single inhalation of nitrous oxide gas may bring about rapid symptom relief in OCD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental: Nitrous Oxide | Experimental | OCD participants in this arm will receive 50%oxygen/50% nitrous oxide admixture for 60 minutes. |
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| Control: Nitrogen | Placebo Comparator | OCD participants in this arm will receive 50%oxygen/50% nitrogen admixture for 60 minutes. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nitrous Oxide | Drug | OCD participants in this arm will receive 50%oxygen/50% nitrous oxide admixture for 60 minutes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in the severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS) | Improvement in OCD severity is measured by the YBOCS (Yale Brown Obsessive-Compulsive Scale), a gold standard measure of obsessions and compulsions. For the YBOCS the minimum units are 0 and Maximum units on the total scale are 40. The higher the number on the YBOCS, the more severe the symptoms. Response is defined as at least a 35% reduction on the YBOCS. | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pavithra Mukunda, MS | Contact | 650-723-4095 | ocdresearch@stanford.edu | |
| Sindu Menon, MBBS | Contact | 650-723-4095 | ocdresearch@stanford.edu |
| Name | Affiliation | Role |
|---|---|---|
| Peter J van Roessel, MD, PhD | Stanford Univeristy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Recruiting | Stanford | California | 94304 | United States |
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| Label | URL |
|---|---|
| Stanford Medicine Faculty Page | View source |
| Rodriguez Lab Website | View source |
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| ID | Term |
|---|---|
| D009771 | Obsessive-Compulsive Disorder |
| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D009609 | Nitrous Oxide |
| D009584 | Nitrogen |
| ID | Term |
|---|---|
| D009589 | Nitrogen Oxides |
| D005740 | Gases |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
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placebo-controlled 2:1 randomized clinical trial.
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| Nitrogen | Drug | OCD participants in this arm will receive 50%oxygen/50% nitrogen admixture for 60 minutes. |
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| D010087 |
| Oxides |
| D017601 | Oxygen Compounds |
| D004602 | Elements |