The " CirB-RNA " cohort aims to create a biological collection associated with clinical and biological data from patients with hepatitis B infection. This project is part of a much larger program that aims to characterize and quantify circulating viral RNAs as a possible new biomarker of hepatitis B functional cure.

Inclusion Criteria:

• Adults patients and minor children over 6 years of age (in Lyon) with acute or chronic hepatitis B or presenting with HBsAg loss (with/without HBs seroconversion). (Co-infected patients with HDV and/or HCV and/or HIV are eligible)
• Patients requiring blood sampling for medical care at the time of the medical appointment.
• Informed patients who do not refuse to participate.
• Persons not affiliated to a social security scheme and persons receiving medical assistance from the state may be asked to participate in the study

Exclusion Criteria:

• Patients participating at the time of the inclusion to an interventional trial evaluating a drug likely to interfere with this study.
• Persons deprived of their liberty by a judicial or administrative decision
• Adults who are subject to a legal protection measure
• Children less than 6 years old (in Lyon)

Patients with hepatitis B infection (acute or chronic) or presenting with HBsAg loss (with/without anti-HBs seroconversion).