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This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.
This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.
15 different Groups are analysed: control Group, 5000ft Group, 8000 ft Group, 10000ft Group and 15000ft Group - all for 15, 30, and 60 minutes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group 15 | No Intervention | Protein expression and emotional test 15 minutes normoxia Interventions: Blood drawing 1 Minute before and 1 Minute after the pressure chamber Phase for Proteomic profiling with 2D-gels Emotional tests (tears, stroop, mood) during the pressure chamber phase | |
| control group 30 | No Intervention | 30 minutes normoxia Interventions: Blood drawing 1 Minute before and 1 Minute after the pressure chamber Phase for Proteomic profiling with 2D-gels Emotional tests (tears, stroop, mood) during the pressure chamber phase | |
| control group 60 | No Intervention | 60 minutes normoxia Interventions: Blood drawing 1 Minute before and 1 Minute after the pressure chamber Phase for Proteomic profiling with 2D-gels Emotional tests (tears, stroop, mood) during the pressure chamber phase | |
| hypoxia 5000ft group 15 | Experimental | Intervention: 15 minutes hypoxia |
|
| hypoxia 5000ft group 30 | Experimental | Intervention: 30 minutes hypoxia |
|
| hypoxia 5000ft group 60 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hypoxia | Procedure | hypoxia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Protein Expression before hypoxia | proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics | Measurement immediately 1 minute before of hypoxia/experiment |
| Protein Expression after hypoxia | proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics | Measurement immediately and at termination (i.e., 1 minute after) of hypoxia/experiment |
| Emotional assessment tears | Emotional tears test | Measurement starts immediately with hypoxia in the pressure chamber. duration 10 minutes |
| Emotional assessment | Emotional stroop test; Williams, J. M. G., Mathews, A., & MacLeod, C. (1996). The emotional Stroop task and psychopathology. Psychological Bulletin, 120, 3-24. | Measurement in the pressure chamber after tears test (i.e. 10 minutes after start). duration 10 minutes |
| Emotional assessment mood | Emotional mood test, POMS mood score. Shukitt-Hale, B., Banderet, L.E., & Lieberman, H.R. (1998). Elevation-dependent symptom, mood, and performance changes produced by exposure to hypobaric hypoxia, The International Journal of Aviation Psychology, 8, 319-334, | Measurement in the pressure chamber after stroop test (i.e. 20 minutes after start). duration 10 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jochen Hinkelbein | University Hospital of Cologne | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Cologne | Cologne | North Rhine-Westphalia | 50937 | Germany |
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| ID | Term |
|---|---|
| D000532 | Altitude Sickness |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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15 different Groups are analysed: control Group, 5000ft Group, 8000 ft Group, 10000ft Group and 15000ft Group - all for 15, 30, and 60 minutes.
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volunteers
| Experimental |
Intervention: 60 minutes hypoxia |
|
| hypoxia 8000ft group 15 | Experimental | Intervention: 15 minutes hypoxia |
|
| hypoxia 8000ft group 30 | Experimental | Intervention: 30 minutes hypoxia |
|
| hypoxia 8000ft group 60 | Experimental | Intervention: 60 minutes hypoxia |
|
| hypoxia 10000ft group 15 | Experimental | Intervention: 15 minutes hypoxia |
|
| hypoxia 10000ft group 30 | Experimental | Intervention: 30 minutes hypoxia |
|
| hypoxia 10000ft group 60 | Experimental | Intervention: 60 minutes hypoxia |
|
| hypoxia 15000ft group 15 | Experimental | Intervention: 15 minutes hypoxia |
|
| hypoxia 15000ft group 30 | Experimental | Intervention: 30 minutes hypoxia |
|
| hypoxia 15000ft group 60 | Experimental | Intervention: 60 minutes hypoxia |
|