The researchers are trying to determine whether ovarian hormones are associated with aging processes and with the risk of developing Alzheimer's disease in women.

The proposed project will enroll a total of 614 women.

Mayo Clinic Rochester Participants: Each women will have 2-3 clinic visits consisting of cognitive testing, tests of physical function, questionnaires, and a blood draw. All women will also undergo clinical neuroimaging, which includes structural MRI, β-amyloid (Aβ) deposition on PET as a biomarker of Aβ pathology, and tau deposition on PET as a marker of neurofibrillary tangles using AV-1451. All participants will have previously participated and will return by invitation only.

Mayo Clinic Jacksonville Participant: Only African American Women will be enrolled at this site. Each women will have 1-3 clinic visits consisting of physical function testing and neuroimaging, which includes structural MRI, β-amyloid (Aβ) deposition on PET as a biomarker of Aβ pathology, and tau deposition on PET as a marker of neurofibrillary tangles using AV-1451.

Mayo Clinic Rochester-

Inclusion Criteria:

• Women who previously participated in this study
• Currently aged 60 years and older
• More than six months post chemotherapy or major surgery requiring general anesthesia
• Willing and able to sign informed consent

Exclusion Criteria:

• Not able to read and speak English
• In hospice
• Claustrophobic
• If undergoing Tau imaging, cannot have QT Prolongation

Mayo Clinic Jacksonville-

Inclusion Criteria:

• African American Women
• Currently aged 60 years and older
• More than six months post chemotherapy or major surgery requiring general anesthesia
• Willing and able to sign informed consent

Exclusion Criteria:

• Not able to read and speak English
• In hospice
• Claustrophobic
• If undergoing Tau imaging, cannot have QT Prolongation