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To evaluate whether personal care products shift the skin microbiome bacteria and diversity after a week of daily use.
Studies have shown that microbiome is important in skin conditions such as eczema, rosacea, acne, and many other skin conditions. Personal care products are widely used on a daily basis but it is not know how these personal care products shift the skin's microbiome. The diversity of the skin microbiome is important in the maintenance of skin equilibrium as a loss of diversity predisposes to development of skin disease.
The aim of this study is to evaluate multiple over the counter products that are used on the face daily to assess how they alter skin microbiome and diversity of microflora on skin after a week of daily treatment.
A second aim of the study is to assess how baseline diversity of microbiome are different based on self-graded skin types.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Serum | Experimental | Burt's Bees Serum |
|
| Serum with Biulin | Experimental | Burt's Bees Serum with Biulin |
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| Serum with Berenew Complex | Experimental | Burt's Bees Serum with Berenew Complex |
|
| Serum with Ecoskin | Experimental | Burt's Bees Serum with Ecoskin |
|
| Serum with Bonicell | Experimental | Burt's Bees Serum with Bonicell |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Burt's Bees Serum | Other | This is a commercially available over-the-counter product. Ingredients: Caprylic/ Capric Trigylceride, Isopropyl Palmitate, Sweet Almond Oil, Lanette O, Water, Cetearyl Glucoside, Gluconolactone ans Sodium Benzoate, Water, Glycerin, Xanthan GUM, Tocopherol. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in skin microflora | Cotton swabs will be used to collect sample skin microbiome bacteria from the cheeks and forehead at baseline and 1 week after daily use of the intervention product. These samples will be analysed and the relative components of the microbiome will be a primary outcome.The collected measurement data will be based on a number of operational taxonomic unit (OTU). | Baseline, 7 days |
| Change in skin microbiome diversity | Cotton swabs will be used to collect sample skin microbiome bacteria from the cheeks and forehead at baseline and 1 week after daily use of the intervention product. These samples will be analysed and change in diversity of the microbiome will constitute a primary outcome. The collected measurement data will be based on a number of operational taxonomic unit (OTU). | Baseline, 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Self-graded skin type | Types are based on the Fitzpatrick Skin Type Questionnaire, which assesses various items on Genetic Disposition, Reaction to Sun Exposure, and Tanning Habits on a score from 0-4. Skin type I corresponds to a total score of 0-7. Skin type II corresponds to a total score of 8-16. Skin type III corresponds to a total score of 17-25. Skin type IV corresponds to a total score of 25-30. Skin type V-VI correspond to a total score of over 30. |
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Inclusion Criteria:
Exclusion Criteria:
Females, aged 20-45
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UC Davis Department of Dermatology, Clinical Trials Unit | Sacramento | California | 95816 | United States |
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|
| Burt's Bees Serum with Biulin | Other | This is a commercially available over-the-counter product. Ingredients: Caprylic/ Capric Trigylceride, Isopropyl Palmitate, Sweet Almond Oil, Lanette O, Water, Cetearyl Glucoside, Gluconolactone ans Sodium Benzoate, Water, Glycerin, Xanthan GUM, Tocopherol, PreBIULIN FOS (GOVA). |
|
| Burt's Bees Serum with Bonicell | Other | This is a commercially available over-the-counter product. Ingredients: Caprylic/ Capric Trigylceride, Isopropyl Palmitate, Sweet Almond Oil, Lanette O, Water, Cetearyl Glucoside, Gluconolactone ans Sodium Benzoate, Water, Glycerin, Xanthan GUM, Tocopherol, Bonicel (Ganaden). |
|
| Burt's Bees Serum with Berenew Complex | Other | This is a commercially available over-the-counter product. Ingredients: Caprylic/ Capric Trigylceride, Isopropyl Palmitate, Sweet Almond Oil, Lanette O, Water, Cetearyl Glucoside, Gluconolactone ans Sodium Benzoate, Water, Glycerin, Xanthan GUM, Tocopherol, BeRenew CLR Complex (CLR). |
|
| Burt's Bees Serum with Ecoskin | Other | This is a commercially available over-the-counter product. Ingredients: Caprylic/Capric Triglyceride, Dimer Dilinoleyl Dimer Dilionoleatem, Silica, Citronellyl Methylcrotonate, Tocopheryl Acetate, Xymenynic Acid, Alpha-glucan Oligosaccharide, Fragrance, Slareolide, Polymnia sonshifolia root juice, Helianthus annuus (sunflower) seed oil, Maltodextrin, Tocopherol, Beta-sitosterol, Lactobacillus, Squalene. |
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| Baseline |