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Mitral valve reconstruction via minimal invasive antero- lateral thoracotomy is done in cardioplegia with a cardioplegic solution, either HTK-Bretschneider (Custidiol®) (a crystalloid intracellular solution) or St. Thomas (a crystalloid extracellular solution).
This study investigates HTK-Bretschneider versus St. Thomas cardioplegic solution regarding peri- and postoperative outcome, especially for cardiac biomarkers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HTK-Bretschneider cardioplegic solution | Patients undergoing mitral valve reconstruction via minimal invasive antero- lateral thoracotomy in cardioplegia with HTK-Bretschneider cardioplegic solution |
| |
| St. Thomas cardioplegic solution | Patients undergoing mitral valve reconstruction via minimal invasive antero- lateral thoracotomy in cardioplegia with St. Thomas cardioplegic solution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cardioplegia with HTK-Bretschneider cardioplegic solution | Other | cardioplegia with HTK-Bretschneider cardioplegic solution |
|
| Measure | Description | Time Frame |
|---|---|---|
| high specific troponin T (hs-TrT) (μg/l) | cardial biomarker for myocardial damage | perioperative during minimal invasive surgery |
| Creatin-Phosphokinase (CK) (U/l) | cardial biomarker for myocardial damage | perioperative during minimal invasive surgery |
| Creatinkinase Muscle- Brain (CK-MB) (U/l) | cardial biomarker for myocardial damage | perioperative during minimal invasive surgery |
| Measure | Description | Time Frame |
|---|---|---|
| mortality rate | number of deaths | from minimal invasive surgery until 30 days post surgery |
| length of stay in intensive care unit (days) | length of stay in intensive care unit (number of days) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with mitral valve reconstruction done via minimal invasive antero- lateral thoracotomy (2009-2018) at Universitätsspital Basel.
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| Name | Affiliation | Role |
|---|---|---|
| Martin Grapow, Prof. Dr. | Klinik für Herzchirurgie, Universitätsspital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinik für Herzchirurgie, Universitätsspital Basel | Basel | 4031 | Switzerland |
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| cardioplegia with St. Thomas cardioplegic solution | Other | cardioplegia with St. Thomas cardioplegic solution |
|
| from minimal invasive surgery until 30 days post surgery |
| ID | Term |
|---|---|
| D008944 | Mitral Valve Insufficiency |
| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D006324 | Heart Arrest, Induced |
| ID | Term |
|---|---|
| D006348 | Cardiac Surgical Procedures |
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019616 | Thoracic Surgical Procedures |
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