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To compare the anesthetic efficacy of the inhalation versus intravenous technique for maintenance of sedation in patients undergoing endoscopy.
A longitudinal, randomized clinical study of 32 patients of both sexes ASA I-III, aged 18-80 years undergoing diagnostic colonoscopy, which was randomly divided into 2 groups. In both, intravenous induction with propofol (2-2.5 mg / kg) was performed, Group A remained sedated with propofol infusion (1-2 mg / kg / min); Group B by inhalation with sevoflurane at a concentration of 2 vol% through a nasal cannula with an oxygen flow.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group Propofol | Experimental | propofol infusion |
|
| Group Sevoflurane | Experimental | inhalation with sevoflurane |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol | Drug | after inicial bolus of propofol, remained sedated with propofol infusion (1-2 mg/kg/min) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | heart rate per minute | During the colonoscopy - an estimated mean time of 20 minutes |
| The Recovery Time | Every 5 minutes till a score of 10/10 achieved on Aldrete Score | 30 min |
| Propofol dosage | propofol rescate bolus administered | During the colonoscopy - an estimated mean time of 20 minutes |
| arterial pressure | non invasive arterial pressure every 5 minutes | During the colonoscopy - an estimated mean time of 20 minutes |
| oxygen saturation | pulse oximetry | During the colonoscopy - an estimated mean time of 20 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| adverse reactions in patients | desaturation, laryngospasm | 1 day (postoperative) |
| Endoscopist Satisfaction | Endoscopist Satisfaction scored from 1-10. Will be tested on a numerical scale from 0 (not satisfied at all) to 10 (fully satisfied) |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D015742 | Propofol |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Sevoflurane | Drug | after inicial bolus of propofol, remained sedated by inhalation with sevoflurane at a concentration of 2 vol% through a nasal cannula with an oxygen flow. |
|
| 60 min |
| Qualitatively assess patient comfort after sedation. | poor, regular or good | Up to 1 hour after completing the study. |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |