What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?

What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)? A Prospective Cohort Study.

This is a multicentre prospective audit to determine the incidence of immunodeficiency in children with IPD.

Aims and/or research question of the project

1. To determine the incidence of primary immunodeficiency in children >2 years who present with IPD
2. To determine the types of immunodeficiency associated with IPD in children

Inclusion Criteria:

• Children aged 0 to 18 years admitted to one of the six centres with IPD.

Exclusion Criteria:

• Children who do not fulfil the age criteria for immunological evaluation at that particular site e.g. aged <2 years at Royal Children's Hospital.
• Children with a known underlying condition predisposing to IPD i.e. nephrotic syndrome.