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Development of palliative care is less effective for patients with hematologic malignancies. Limited data is available for end of life care in this population, moreover with thrombocytopenic patients. Thrombopenia is a frequent complication, specific of bone marrow involvement in those diseases or its treatments. Yet, a few studies was interested in, whereas platelet transfusion is the only treatment indicated. As it represent a scarce, limited resource, the ethical principles are in conflict in this setting.
The purpose of this study was to describe retrospectively platelet transfusion in the six last few month of life of patients with hematologic malignancies at the CHU of Besançon (France) between 01/07/15 and 31/12/16.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patient transfused in platelet in the 6 last months of life | patient with hematological malignancies follow or hospitalised at least once in CHU of Besancon died in the period of the study transfused at least once in the 6 months of life |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| descriptive | Other | evaluate in number and efficacy platelet transfusion at the end of life, demographic characteristic are also noted |
|
| Measure | Description | Time Frame |
|---|---|---|
| evaluate frequency of platelet transfusion at the end of life | to calculate the number of platelet transfusion at the end of life. The number of platelet transfusion between 6 months and death are collected in each periods of 2 weeks to calculate the number of transfusion per patient during each 2 weeks. | 18 months (between 07/01/2015 and 12/31/2016) |
| evaluate efficacy of prophylactic platelet transfusion at the end of life | to calculate the platelet yield in percentage | 18 months (between 07/01/2015 and 12/31/2016) |
| evaluate efficacy of non prophylactic platelet transfusion at the end of life | to calculate the transfusional interval between 2 platelet transfusion in days | 18 month (between 07/01/2015 and 12/31/2016) |
| Measure | Description | Time Frame |
|---|---|---|
| demographic characteristic | characteristic of patient (age, diagnosis,location of death, palliative care received...) | 18 months (between 07/01/2015 and 12/31/2016) |
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Inclusion Criteria:
Exclusion Criteria:
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patient with hematological malignancies,transfused in platelet at least once in the last 6 months of life, hospitalised or follow up at the CHU of Besancon at least once and dead during the period of the study
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| Name | Affiliation | Role |
|---|---|---|
| regis aubry, ph | Centre Hospitalier Universitaire de Besancon | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Moracchini | Besançon | 25000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23208312 | Background | Hochsmann B, Moicean A, Risitano A, Ljungman P, Schrezenmeier H. Supportive care in severe and very severe aplastic anemia. Bone Marrow Transplant. 2013 Feb;48(2):168-73. doi: 10.1038/bmt.2012.220. Epub 2012 Dec 3. | |
| 27550559 | Background | Sherbeck JP, Boss RD. Ethical Questions about Platelet Transfusions at the End of Life. AMA J Ethics. 2016 Aug 1;18(8):764-70. doi: 10.1001/journalofethics.2016.18.8.ecas1-1608. |
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patient were dead during the period of recruitment. Characteristic of patient could be used for other purpose
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| 17298272 | Background | Salacz ME, Lankiewicz MW, Weissman DE. Management of thrombocytopenia in bone marrow failure: a review. J Palliat Med. 2007 Feb;10(1):236-44. doi: 10.1089/jpm.2006.0126. |
| 8857246 | Background | Lassauniere JM, Bertolino M, Hunault M, Zittoun R, Verspieren P, Moh-Klaren J, Jaulmes D, Colombat P. Platelet transfusions in advanced hematological malignancies: a position paper. J Palliat Care. 1996 Spring;12(1):38-41. |
| 2414307 | Background | Boggs DR. Jehovah's Witnesses with leukemia. Hosp Pract (Off Ed). 1985 Mar 15;20(3):92, 94-5, 98 passim. doi: 10.1080/21548331.1985.11703015. No abstract available. |
| 29285557 | Result | Wang WS, Ma JD, Nelson SH, Revta C, Buckholz GT, Mulroney C, Roeland EJ. Transfusion practices at end of life for hematopoietic stem cell transplant patients. Support Care Cancer. 2018 Jun;26(6):1927-1931. doi: 10.1007/s00520-017-4023-y. Epub 2017 Dec 28. |