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| ID | Type | Description | Link |
|---|---|---|---|
| 81703240 | Other Grant/Funding Number | The National Natural Science Fund |
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| Name | Class |
|---|---|
| National Natural Science Foundation of China | OTHER_GOV |
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The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. Biological samples including blood and tissue samples are also collected from mothers and their children.
Maternal and child health is of great concern globally. Early life phase of a fetus and infant is a critical period for the development of health and disease in the whole life. Exposure of negative environmental, nutritional and lifestyle factors in pregnant women during this period can have adverse effects on fetal and infant. In addition, for mothers, complications during pregnancy could also have a negative effect on long-term health of mothers, such as diabetes, hypertension. Thus, the Peking University Birth Cohort in Tongzhou is primarily aimed to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. Biological samples including blood and tissue samples are also collected from mothers and their children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exposure group | Group with environmental, nutritional or lifestyle exposures |
| |
| Non-exposed group | Group without any environmental, nutritional and lifestyle exposures |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | This is an observational study without any intervention |
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| Measure | Description | Time Frame |
|---|---|---|
| Numbers of participants with pregnancy complications | Including gestational diabetes, gestational hypertension, anemia, and hypothyroidism during pregnancy | At delivery |
| Numbers of participants with adverse pregnancy outcomes | Including preterm birth, low birth weight, macrosomia, abortion, stillbirth, and birth defects. | At delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Weight in kilogram changes during childhood | Measured by health professionals in clinic | At birth and age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years |
| Height in centimeter changes during childhood |
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Inclusion Criteria:
Exclusion Criteria:
Pregnant women have chronic disease before pregnancy, including diabetes，hypertension, liver disease and kidney disease.
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Pregnant women and their children in Tongzhou, China
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| Name | Affiliation | Role |
|---|---|---|
| Haijun Wang, Ph.D | Peking University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University | Beijing | Beijing Municipality | 100191 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31958310 | Derived | Jin C, Lin L, Han N, Zhao Z, Liu Z, Luo S, Xu X, Liu J, Wang H. Effects of dynamic change in fetuin-A levels from the first to the second trimester on insulin resistance and gestational diabetes mellitus: a nested case-control study. BMJ Open Diabetes Res Care. 2020 Jan;8(1):e000802. doi: 10.1136/bmjdrc-2019-000802. |
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| ID | Term |
|---|---|
| D016640 | Diabetes, Gestational |
| D046110 | Hypertension, Pregnancy-Induced |
| D047928 | Premature Birth |
| D009765 | Obesity |
| D000740 | Anemia |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
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During pregnancy: maternal blood. At delivery: cord blood，umbilical cord and placenta. During childhood: blood.
Measured by health professionals in clinic |
| At birth and age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years |
| Early Child development 1 | Measured by Ages&Stages Questionnaires (ASQ).There are 6 questions in each of 5 domains of development: communication, gross motor, fine motor, problem-solving skills, and adaptive skills. Each question is given a 10 (yes), 5 (sometimes), or 0 (not yet) score according to the parents' answers. The sum scores (range from 0 to 300) and scores for each domain (range from 0 to 60) are calculated. Chinese norms are available for each domain, and any domain screened <2 SDs below the mean is considered a positive screening. A higher ASQ score means better development. | Age at 6 weeks and 3 years |
| Early Child development 2 | Measured by Denver Developmental Screening Test (DDST). DDST comprises 125 test items grouped into four domains of child development: 25 personal-social (PS), 29 fine motor (FM), 39 language (LA) and 32 gross motor (GM). These test items are administered using a bell, glass bottle, set of 10 blocks, rattle, pencil, tennis ball, yarn, raisins, cup, white doll, white paper, and baby bottle. A child's raw score on each test item is marked as tested pass, failure, refusal, or no opportunity. The result of the test is labeled as "normal," "suspect" or "abnormal". Normal development means that there is no delay or at the maximum one warning. Abnormal development means that there is one or more than one delay situation. Suspicious development means that it is a situation involving one delay, one delay and one warning or two or more than two warnings. The number of children with normal, suspect or abnormal development is calculated. | Age at 8-12 months |
| Incidence of diabetes mellitus in women | Measured by health professionals in clinic | 6 weeks after delivery and 3 years after delivery |
| Incidence of hypertension in women | Measured by health professionals in clinic | 6 weeks after delivery and 3 years after delivery |
| Incidence of child overweight and obesity | Measured by health professionals in clinic | Age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years |
| The proportion of children with warning signs | Measured by warning signs screening | Age at 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years |
| Fetal Biparietal Diameter | Measured by health professionals in clinic with ultrasound | At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
| Fetal Head Circumference | Measured by health professionals in clinic with ultrasound | At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
| Fetal Abdominal Circumference | Measured by health professionals in clinic with ultrasound | At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
| Fetal Femur Length | Measured by health professionals in clinic with ultrasound | At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
| Fetal Humerus Length | Measured by health professionals in clinic with ultrasound | At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week. |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |