Sponsor decision

The purpose of this study is to evaluate the efficacy and safety of Leningrado association on the treatment of hypertension.

Inclusion Criteria:

• Participants aged 18 years or more;
• Participants diagnosed with hypertension (mild to moderate), mild to moderate cardiovascular risk, not controlled by monotherapy and/ or lifestyle modification;

Exclusion Criteria:

• Any clinical and laboratory findings that, in the judgment of the investigator, may interfere with the safety of research participants;
• BP ≥ 180/110 mmHg;
• Participants with BMI (body mass index) ≥ 40 Kg/m2;
• Previous diagnosis of secondary hypertension;
• History of taget organ damage;
• History of cardiovascular, hepatic and renal disease;
• History of gout, diabetes mellitus and hypokalemia;
• Current medical history of cancer;
• Current smoking;
• History of alcohol abuse or drug use;
• Pregnancy or risk of pregnancy and lactating patients;
• Known allergy or hypersensitivity to the medicines components used during the clinical trial;
• Participation in clinical trial in the year prior to this study.