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The relation between the timing of COC denudation and oocyte /embryo quality is controversial. The aim of this study is to examine whether timing of denudation of sibling oocytes has any effect on embryo quality.
Retrieved sibling cumulus-oocyte complexes (COCs) will be randomly divided into two groups, in the first group denudation will be in 30 minutes after oocyte retrieval, in second group denudation will take place after 2 hours of incubation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| early denudation | Cumulus-oocyte complexes will be denudated in 30 min after oocyte retrieval |
| |
| late denudation | Denudation will be done 2 hr after oocyte retrieval |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| early denudation | Other | COCs will be denudated in 30 min after oocyte retrieval |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Number of good quality cleavage embryos | Quality of embryos will be assessed morphologically on day 3 | 3 days after microinjection |
| Embryo utilization rate | Embryo utilization rate is defined as the number of embryos utilized (transferred or cryopreserved) per number of 2PN zygotes. | 1 week after microinjection |
| Measure | Description | Time Frame |
|---|---|---|
| Fertilization rate | Proportion of injected oocytes with 2PN the day after injection | 16-18 hour after microinjection |
| Cleavage rate | Proportion of cleaved zygotes on day 2 |
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Inclusion Criteria:
Exclusion Criteria:
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Those infertile patients eligible for the study design who are planned to be treated with microinjection and has given written informed consent
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Acibadem Altunizade Hospitai | Recruiting | Istanbul | 34785 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| late denudation |
| Other |
COCs will be denudated 2 hr after oocyte retrieval |
|
| 2 days after microinjection |
| Blastulation rate | Blastocyst rate per oocyte | 1 week after microinjection |
| D000091662 | Genital Diseases |
| D007246 | Infertility |