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A sleep deprivation protocol combined with state-of-the-art, simultaneous positron emission tomography and magnetic resonance spectroscopy imaging will be employed to investigate the effects of sleep deprivation and aging on hypothesized molecular markers of sleep need.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sleep deprivation young men | Experimental | Young study participants will complete four nights in the sleep laboratory, whereas they will stay awake during one night. PET brain imaging will be conducted at the same circadian time on three consecutive afternoons (prior, during and after prolonged wakefulness). Additionally, validated tests of vigilance and cognitive performance will be administered and the brain waves will be recorded in wakefulness and sleep. |
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| Sleep deprivation older men | Experimental | Older study participants will complete four nights in the sleep laboratory, whereas they will stay awake during one night. PET brain imaging will be conducted at the same circadian time on three consecutive afternoons (prior, during and after prolonged wakefulness). Additionally, validated tests of vigilance and cognitive performance will be administered and the brain waves will be recorded in wakefulness and sleep. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prolonged wakefulness | Behavioral | 40 hours of prolonged wakefulness |
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| Measure | Description | Time Frame |
|---|---|---|
| Sleep-wake induced change in cerebral availability of mGluR5 (metabotropic glutamate receptors of subtype 5) | Positron emission tomography | Change from baseline metabotropic glutamate receptors of subtype 5 availability after 33 hours of prolonged wakefulness and 8 hours of recovery sleep |
| Measure | Description | Time Frame |
|---|---|---|
| Sleep-wake induced change in glutamate concentration in prefrontal cortex and basal ganglia | Magnetic resonance spectroscopy | Change from baseline glutamate concentration after 33 hours of prolonged wakefulness and 8 hours of recovery sleep |
| Sleep-wake induced change in potential molecular markers of sleep need |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hanspeter Landolt, Prof | University of Zurich, Institute of Pharmacology and Toxicology | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31304973 | Derived | Weigend S, Holst SC, Treyer V, O'Gorman Tuura RL, Meier J, Ametamey SM, Buck A, Landolt HP. Dynamic changes in cerebral and peripheral markers of glutamatergic signaling across the human sleep-wake cycle. Sleep. 2019 Oct 21;42(11):zsz161. doi: 10.1093/sleep/zsz161. |
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| ID | Term |
|---|---|
| D012892 | Sleep Deprivation |
| ID | Term |
|---|---|
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
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microRNAs, fragile X mental retardation protein, and brain-derived neurotrophic factor concentrations in peripheral blood |
| Change from baseline microRNA, fragile X mental retardation protein and brain-derived neurotrophic factor concentrations after 33 hours of prolonged wakefulness and 8 hours of recovery sleep |
| Sleep-wake induced change in sleep electroencephalogram (EEG) | Spectral composition of the EEG during sleep | Change from all-night baseline sleep EEG in 8 hours of recovery sleep after 33 hours of prolonged wakefulness |
| Sleep-wake induced change in waking electroencephalogram (EEG) | Spectral composition of the EEG in wakefulness | Change from baseline waking EEG during 33 hours of prolonged wakefulness and after 8 hours of recovery sleep |
| Sleep-wake induced change in subjective state | Subjective sleepiness as quantified with the Stanford Sleepiness Scale (range: 1 to 7) | Change from baseline sleepiness during 33 hours of prolonged wakefulness and after 8 hours of recovery sleep |
| Sleep-wake induced change in cognitive performance | Cognitive performance battery including tasks measuring sustained attention, executive functioning and working memory | Change from baseline cognitive performance during 33 hours of prolonged wakefulness and after 8 hours of recovery sleep |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |