Sleep for Stroke Management and Recovery Trial
Sleep for Stroke Management and Recovery Trial
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.
Sleep SMART has a prospective, randomized, open-label, blinded-endpoint (PROBE) design. It is a multi-site, parallel-group superiority trial that compares 6 months of OSA treatment to usual care. The study includes two trials: a prevention study with an embedded recovery trial. 3062 subjects will be randomized over 5 years at 110 sites within the NINDS-funded StrokeNet clinical trials network.
Current Inclusion Criteria, as of 6/28/2024:
Previous Inclusion Criteria, prior to 6/28/2024:
1. Ischemic stroke or TIA with ABCD ≥4, within prior 14 days.
Exclusion Criteria (for entire time period):
Neptune City, New Jersey 07753, United States