Stereotactic Body Radiation Therapy Versus Radiofrequency Ablation for Small Renal Masses

A Prospective Randomized Pilot Trial of Stereotactive Body Radiation Therapy Versus Radiofrequency Ablation for the Management of Small Renal Masses.

The execution of this study is pertinent to evaluating SBRT's short- and long-term efficacy and safety in the treatment of SRMs. This study will be the first to compare RFA and SBRT in the treatment of SRMs.

Inclusion Criteria:

• Patients ≥18 years of age and capable of providing informed consent
• Patients scheduled for treatment of their SRM using SBRT or RFA
• Patients who received a biopsy of their SRM prior to their scheduled SBRT or RFA treatment
• Patients who are willing to have a biopsy 12 months post-procedure
• Patients with renal tumor(s) ≤ 4.0 cm

Exclusion Criteria:

• Patients with large renal tumor(s)>4.0 cm
• Patients who are unable to have a general anesthetic
• Patients who did not receive a biopsy of their SRM prior to their scheduled SBRT or RFA treatment
• Patients who are unable to comply with post-operative and/or follow-up protocol/phase of study
• Evidence of metastatic disease
• Uncorrectable bleeding diathesis