Clinical Feasibility and Efficacy of Intermittent Use of a Fasting Mimicking Diet in the Treatment of Type 2 Diabetes

Clinical Feasibility and Efficacy of Intermittent Use of a Fasting Mimicking Diet in the Treatment of Type 2 Diabetes

In this randomized, controlled, assessor blinded and prospective intervention study the investigators will evaluate the clinical feasibility and effectiveness of intermittent use of a fasting mimicking diet in patients with type 2 diabetes mellitus compared to usual care.

100 individuals (men or women, ethnicity not specified) with type 2 diabetes and a BMI≥ 27, who are treated with diet only and have a HbA1c > 48, or who are treated with diet and a dose of metformin can participate in the study. Participants will use a fasting-mimicking diet for 5 consecutive days per month. For the other days, there are no regulations. During follow-up of one year, several study parameters will be measured including HbA1c and antidiabetic medication dosage.

Inclusion Criteria:

• Diagnosis of type 2 diabetes
• Age > 17 years and <75 years
• Treatment with diet only and have a HbA1c > 48, or treatment with diet and metformin
• BMI ≥ 27

Exclusion Criteria:

• Recent myocardial infarction (< 6 months)
• Creatinine clearance < 30 ml/min/1,73m2 (MDRD)
• Pregnancy
• Contraindications for MRI
• Allergy for nuts, sesame, soya or another ingredient of the diet
• History of syncope with calorie restriction in the past
• Any significant other disease (at the discretion of the investigator)