B cell malignancies comprise a heterogeneous group of neoplasms including a vast majority of non-Hodgkin's lymphomas (NHL), lymphoblastic leukemias (ALL) and chronic lymphocytic leukemias (CLL). Current treatments for B cell malignancies include chemotherapy, radiation therapy, bone marrow transplantation, and peripheral blood stem cell transplantation. Despite these treatment modalities, most patients will remain incurable. Welgenaleucel (UWC19) is a CD19-directed genetically-modified autologous immunotherapy. This study is designed to evaluate safety and feasibility of administering Welgenaleucel (UWC19) transduced with anti-CD19 lentiviral vector to patients with advanced refractory hematologic malignancies, including DLBCL and ALL.

Inclusion Criteria:

• CD19+ leukemia or lymphoma patients with no available curative treatment options who have limited prognosis with currently available therapies
• Absolute lymphocyte count, ALC )≧600/μl
• HIV, HTLV, Syphilis negative
• GPT ≦200 U/L
• Cr ≦221 umol/L
• Adequate venous access for apheresis, and no other contraindications for leukapheresis.
• Voluntary informed consent is given.

Exclusion Criteria:

• Body weight < 20Kg
• Pregnant women.
• Uncontrolled active infection.
• Active hepatitis B or hepatitis C infection.
• Concurrent use of systemic steroids. Recent or current use of inhaled steroids is not exclusionary.
• Previously treatment with any gene or cell therapy products.
• Any uncontrolled active medical disorder that would preclude participation as outlined.
• Expected survival< 12 weeks
• Received investigational drug or device within 30 days pre-trial;
• Patients with any other serious diseases considered by the investigator(s) not in the condition to enter the trial.