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This study aimed to clarify whether strength training or aerobic training could bring more benefits for patients with dementia, another study is to clarify whether isokinetic or isotonic training could bring more benefits for patients with mild cognitive impairment
Exercise training has been evidenced to bring various of benefits for patients with dementia in past studies. However, whether strength training or aerobic training could bring better benefits has not been confirmed in the past. This study designed to recruit 30 patients with mild dementia in the first year. Every patient will receive strength training using dumbbells, butterfly machine and vertical leg press machine for four weeks. Outcome measures including self care ability, cognitive function, MCP-1, BDNF and IGF-1 levels, and the degree of depression will be recorded before and after the training. In the second year, the investigators also designed to recruit 31 patients with mild dementia. These participants will instead receive aerobic training using stationary bicycle for four weeks. The same outcome measures will be tested as in the first year. The other part of the study recruited 46 patients with mild cognitive impairment, who were randomized into either a four-week isokinetic or isotonic training program. All cases were evaluated by isokinetic peak torque, 36-item Short Form Survey (SF-36), Mini-Mental State Examination (MMSE), Barthel Index, geriatric depression scale (GDS-15), and Timed Up and Go test (TUG test) before and after each kind of training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Strength training | Experimental | Muscle strength training programs |
|
| Aerobic training | Experimental | Aerobic training programs |
|
| Isokinetic training | Experimental | Isokinetic training |
|
| Isotonic training | Experimental | Isotonic training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Strength training | Device | Using dumbbells, butterfly machine and vertical leg press machine for strength training, 12 repetition maximum weight for 12 repetition, three times a day, five days a week, for a total of four weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Barthel index | To evaluate function of activities of daily living, range from 0-100, higher values represent a better outcome | 4 weeks |
| Mini-mental state examination | To evaluate cognitive function, range from 0-30, higher values represent a better outcome | 4 weeks |
| Montreal Cognitive Assessment | To evaluate cognitive function, range from 0-30, higher values represent a better outcome | 4 weeks |
| Geriatric Depression Scale | To evaluate patient's depression status, range from 0-15, higher values represent a worse outcome | 4 weeks |
| Timed up and go test | Measure the time taken by a patient to stand up from a chair, walk three meters, return, and sit back on the chair | 4 weeks |
| SF-36 | consists of 36 questions categorized into 8 subdomains, including physical functioning, role limitations due to physical health, pain, general health condition, vitality, social functioning, role limitations due to emotional problems, and emotional well-being. | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of serum brain derived neurotrophic factor (BDNF) | Increasing BDNF level is related to preventing neurodegeneration. | 4 weeks |
| Concentration of plasma insulin-like growth factor-1 (IGF-1) |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yuan-Yang Cheng, MDPHD | Department of rehabilitation of Taichung Veterans General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Taichung Veterans General Hospital | Taichung | 40705 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32084347 | Derived | Liu IT, Lee WJ, Lin SY, Chang ST, Kao CL, Cheng YY. Therapeutic Effects of Exercise Training on Elderly Patients With Dementia: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2020 May;101(5):762-769. doi: 10.1016/j.apmr.2020.01.012. Epub 2020 Feb 19. |
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| ID | Term |
|---|---|
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D019965 | Neurocognitive Disorders |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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comparison of therapeutic effect between aerobic and strength training on dementia patient, and comparison of therapeutic effect between isokinetic and isotonic training on patients with mild cognitive impairment
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| Aerobic training | Device | Using stationary bicycle to perform cardiopulmonary endurance training in 50-70 heart rate reserve for 20 minutes, five days per week, for a total of four weeks |
|
| Isokinetic trinaing | Device | Using Biodex isokinetic dynanometer and set it in isokinetic mode in 60 degree per second |
|
| Isotonic training | Device | Using Biodex isokinetic dynanometer and set it in isotonic mode at 60% of the maximal peak torque |
|
Lower plasma level of IGF-1 is associated with an increased risk of developing Alzheimer's dementia, and higher levels of it may protect against neurodegeneration.
| 4 weeks |
| Concentration of plasmamonocyte chemotactic protein-1 (MCP-1) | The elevation of MCP-1 concentration usually means the progression of systemic inflammation. | 4 weeks |
| D001523 | Mental Disorders |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |