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| Name | Class |
|---|---|
| Project Group for Automation in Medicine and Biotechnology PAMB, Mannheim | UNKNOWN |
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Long-term aim is the definition of a setup of mobile sensors and their integration in a mobile infrastructure that allows the prediction of stress related alcohol intake in an ambulatory setting. Here, we aim to identify stress- and alcohol cue-related physiological markers in a lab experiment to assess interactions between acute psychological vs. physical stress exposure and alcohol cue-exposure regarding their effects on measures relevant for the development and maintenance of Alcohol Use Disorder (AUD). Further, we aim to identify neural correlates in brain circuits of motivational, cognitive, and affective processing. In addition to applying established stress-related markers, we will integrate innovative sensor-based measures.
In patients with Alcohol Use Disorder (AUD) stress exposure is known to affect craving, cue-reactivity and relapse risk. Here, we aim to identify stress- and alcohol cue-related physiological markers in a lab experiment to assess interactions between acute psychological vs. physical stress exposure and alcohol cue-exposure regarding their effects on (1) alcohol craving and related markers (attentional bias to alcohol-cues, implicit association task, neural cue-reactivity), (2) their predictive capacity for future alcohol intake, (3) the identification their neural correlates in brain circuits of motivational, cognitive, and affective processing. In addition to applying established stress-related markers (cortisol in saliva, heart-rate variability, systolic blood pressure and electrodermal activity), (4) we will integrate portable sensors (wearables) to allow a future integration in ambulatory assessments and to test innovative measures currently under investigation (e.g. voice stress analysis) to identify whether these additional parameters increase the predictive significance. Our long-term aim is the definition of a setup of mobile sensors and their integration in a mobile infrastructure that allows the prediction of stress related alcohol intake in an ambulatory setting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | Participants reads newspaper before Barlab-Exposure |
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| Experimental 1 (Distress) | Experimental | Participants undergo the Trier Social Stress Test before Barlab-Exposure |
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| Experimental 2 (Eustress) | Experimental | Participants ride an ergometer before Barlab-Exposure |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trier Social Stress Test | Behavioral | Test to induce high levels of acute social stress, including actors and a faked exam situation |
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| Measure | Description | Time Frame |
|---|---|---|
| change in heart rate | heart rate acquired with ear clip (continuous time series) | at examination day: continuous measurement throughout the whole experiment (except during MRI scanning); duration around 2 hours; starting 1 hour 50 minutes after arrival of the proband |
| change in heart rate variability | heart rate variability acquired with ear clip (continuous time series) | at examination day: continuous measurement throughout the whole experiment (except during MRI scanning); duration around 2 hour; starting 1 hour 50 minutes after arrival of the proband |
| change in blood pressure (systolic and diastolic) | acquired with pressure sleeve | at examination day: 6 time points measured throughout the whole experiment (except during MRI scanning); at hours:minutes 2:20, 2:50, 3:20, 3:50, 4:50, 5:05 after arrival of the proband |
| change in electrodermal activity | time series acquired with body sensor | at examination day: continuous measurement throughout the whole experiment (except during MRI scanning); duration around 2 hour; starting 1h 50min after arrival of the proband |
| neural alcohol-related cue-reactivity | % signal change, measured with fMRI; paradigm Vollstädt-Klein et al. 2010; [% signal change is not a change over time; it is measured during one experimental session] | at examination day: measured directly after the behavioral tasks at the end of the lab experiment |
| neural inhibition processing | % signal change, measured with fMRI; stop-signal reaction time task (Fauth-Buhler et al. 2012) [% signal change is not a change over time; it is measured during one experimental session] |
| Measure | Description | Time Frame |
|---|---|---|
| alcohol consumption | self-report using the instrument Form90 (Scheurich et al. 2005) | 12 months follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Falk Kiefer, Prof. | Central Institute of Mental Health, Mannheim | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinik für Abhängiges Verhalten, Zentralinstitut für Seelische Gesundheit | Mannheim | Baden-Wurttemberg | 68159 | Germany |
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| ID | Term |
|---|---|
| D000437 | Alcoholism |
| D015775 | Fractures, Stress |
| D012008 | Recurrence |
| D016739 | Behavior, Addictive |
| D012309 | Risk-Taking |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| ID | Term |
|---|---|
| D004191 | Behavioral Disciplines and Activities |
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| Ergometer | Behavioral | Riding ergometer |
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| Barlab-Exposure | Behavioral | Participants are exposed to a bar situation with different sorts of alcohol available. They sniff at water and at one alcoholic drink. |
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| Reading Newspaper | Behavioral | Participants read newspaper |
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| at examination day: measured directly after the behavioral tasks at the end of the lab experiment |
| neural emotion processing | % signal change, measured with fMRI; faces task (Hariri et al. 2002) [% signal change is not a change over time; it is measured during one experimental session] | at examination day: measured directly after the behavioral tasks at the end of the lab experiment |
| resting state activity | resting state connectivity measured with fMRI | at examination day: measured directly after the behavioral tasks at the end of the lab experiment |
| fMRI | neural alcohol-related cue-reactivity, stop-signal reaction time task, emotion processing and resting state fMRI | at examination day: measured directly after the behavioral tasks at the end of the lab experiment |
| attentional bias to alcohol cues | measured with reaction time differences (in milliseconds) using the dotprobe-task (Vollstädt-Klein et al. 2009) [reaction time differences is not a change over time; it is measured during one experimental session] | at examination day: measured directly after the stress task / newspaper reading; before "implicit alcohol association" and MRI session |
| implicit alcohol association | measured with reaction time differences (in milliseconds) using the implicit association task (Wiers et al. 2016) [reaction time differences is not a change over time; it is measured during one experimental session] | at examination day: measured after the stress task / newspaper reading, directly after the "attentional bias to alcohol cues" ; before MRI session |
| change in level of cortisol | cortisol measured in saliva as a stress marker | at examination day: 6 time points measured throughout the whole experiment (except during MRI scanning); at hours:minutes 2:20, 2:50, 3:20, 3:50, 4:50, 5:05 after arrival of the proband |
| change in voice stress pattern | audio file of participants' voice for voice stress pattern analysis will be recorded. From this a multivariate measure (i.e. multivariate vector) will be acquired (including frequency, loudness etc.) | at examination day: 6 time points measured throughout the whole experiment (except during MRI scanning); at hours:minutes 2:20, 2:50, 3:20, 3:50, 4:50, 5:05 after arrival of the proband |
| change in alcohol urges | self-report questionnaire: "Alcohol Urge Questionnaire (AUQ)"; Bohn et al. 1995 | at examination day: 6 time points measured throughout the whole experiment (except during MRI scanning); at hours:minutes 2:20, 2:50, 3:20, 3:50, 4:50, 5:05 after arrival of the proband |
| change in alcohol craving | self-report "How strong is your craving for alcohol?": reported on a visual analogue scale ranging from 0 to 100 | at examination day: 6 time points measured throughout the whole experiment (except during MRI scanning); at hours:minutes 2:20, 2:50, 3:20, 3:50, 4:50, 5:05 after arrival of the proband |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003192 | Compulsive Behavior |
| D007175 | Impulsive Behavior |
| D001519 | Behavior |