The EMPOWeR study is proposed as a cohort study with longitudinal follow-up to determine rates of genetic mutations among men with or at-risk for prostate cancer to address the various facets of genetic education and counseling for optimized genetic assessment and wellness of men. The results will inform practice guidelines and future studies for maximal impact of genetic evaluation of men for inherited prostate cancer.

Inclusion Criteria:

• Men with a personal history of prostate cancer
• Unaffected males who are at higher risk for prostate cancer (family history of prostate cancer or African American males)
• Men who previously tested positive for a mutation may be eligible for Specific Aims 2-7
• Men with a known familial mutation
• Men who previously participated in the Genetic Evaluation of Men (GEM) study (IRB#14S.546) will be offered participation in EMPOWeR -

Exclusion Criteria:

• Age < 18 years
• Mental or cognitive impairment that interferes with ability to provide informed consent

As this is a study on prostate cancer, women and children are not included. Minorities meeting eligibility criteria may participate in the study.

Any male >18 years with prostate cancer is eligible. Furthermore, unaffected men at higher risk for prostate cancer (family history of prostate cancer or African American males) are also eligible for the study. Men will be approached by their providers or study staff during their clinical appointments for participation. Emails or mailings may also be sent to introduce the study to patients and to contact us for participation. Men who previously participated in the Genetic Evaluation of Men (GEM) study (IRB#14S.546) will be offered participation in EMPOWeR.