Evaluation and Management for Prostate Oncology, Wellness, and Risk (EMPOWeR)

Evaluation and Management for Prostate Oncology, Wellness, and Risk (EMPOWeR)

The EMPOWeR study is proposed as a cohort study with longitudinal follow-up to determine rates of genetic mutations among men with or at-risk for prostate cancer to address the various facets of genetic education and counseling for optimized genetic assessment and wellness of men. The results will inform practice guidelines and future studies for maximal impact of genetic evaluation of men for inherited prostate cancer.

Inclusion Criteria:

• Men with a personal history of prostate cancer
• Unaffected males who are at higher risk for prostate cancer (family history of prostate cancer or African American males)
• Men who previously tested positive for a mutation may be eligible for Specific Aims 2-7
• Men with a known familial mutation
• Men who previously participated in the Genetic Evaluation of Men (GEM) study (IRB#14S.546) will be offered participation in EMPOWeR -

Exclusion Criteria:

• Age < 18 years
• Mental or cognitive impairment that interferes with ability to provide informed consent