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Investigation of the effect of intraoperative lung protection high PEEP maneuver on ischemic reperfusion injury in patients undergoing pulmonary endarterectomy.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease characterized by progression of thromboembolism obstructing pulmonary arteries as an organized tissue. Pulmonary thromboendarterectomy (PTE) is a treatment option for chronic thromboembolic pulmonary disease. However, PTE is associated with specific postoperative complications, such as pulmonary edema and right ventricular failure due to reperfusion injury, with a significant mortality rate of 7% to 24%. Some strategies have been proposed to reduce lung injury after PTE, such as rectification maneuvers and high PEEP. The aim of this study was to investigate the effect of intraoperative lung protection high PEEP maneuver in patients undergoing pulmonary endarterectomy for ischemic reperfusion injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high PEEP | Active Comparator | 35 cm/H2O PEEP, 2-3 ml/kg tidal volume,45 seconds, after cardiopulmonary bypass |
|
| control group | Active Comparator | 6 cm/H2O PEEP, 6-8 ml/kg tidal volume, continues, after cardiopulmonary bypass |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PEEP | Other | performing 35 cm/H2O PEEP and 2-3 ml/kg tidal volume |
| |
| Measure | Description | Time Frame |
|---|---|---|
| free oxygen radicals levels | Superoxide dismutase (SOD) activity will be measured by modification of the method of Sun et al. and Protein carbonyl groups will be determined by volume modification according to Reznick and Packer method. | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| postoperatif outcome - Duration of stay in the intensive care unit and hospital stay | Duration of stay in the intensive care unit and hospital stay after pte operation | 10 day |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mustafa EMRE Gurcu | Istanbul | 34865 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D015427 | Reperfusion Injury |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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prospective, randomized
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| control group |
| Other |
performing 6 cm/H2O PEEP and 6-8 ml/kg tidal volume |
|
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008722 | Methods |