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During pregnancy and lactation, the consumption of PUFA n-3, through the consumption of food products that contain more ALA than conventional products, could impact nutritional and non-nutritional breast milk quality (immune criteria, metabolites, hormones), and also the implantation of the intestinal microbiota of the newborn, which is involved in preservation of short term and long term health of the child.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental Group | Experimental | consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day |
|
| Control Group | Placebo Comparator | no consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day. This group will receive Système U vouchers. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary advice | Device | participants will benefit of dietary device 30-minute dietary advice carried out by a doctor at the University Hospital of Rennes, in order to provide nutritional advice adapted to pregnant women. |
| Measure | Description | Time Frame |
|---|---|---|
| Level of α-linolenic acid in milk | The primary evaluation criterion is the level of α-linolenic acid in milk on the 21st postpartum day. | on the 21st postpartum day. |
| Measure | Description | Time Frame |
|---|---|---|
| The α-linolenic acid level of breast milk | The α-linolenic acid level of breast milk at the 45th postpartum day; | at the 45th postpartum day; |
| The fatty acid content of breast milk ; | The fatty acid content of breast milk on the 21st and the 45th postpartum days; |
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Inclusion Criteria:
Non-inclusion criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CIC CHU de Rennes | Rennes | 35000 | France |
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| Consumption of Bleu-Blanc-Coeur products | Other | consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day |
|
| No consumption of Bleu-Blanc-Coeur products | Other | no consumption of Bleu-Blanc-Cœur products from the 29th week of amenorrhea to the 45th postpartum day. This group will receive Système U vouchers. |
|
| Blood sample | Biological | the fatty acid profile of the women red blood cells of the woman wil be test at the inclusion and at 21 days post-partum |
|
| Contact | Other | Participants of the group A will be contacted by phone,sms, mail by a technician every 15 days from 7th month of pregnancy to the 8th month of pregnancy and then every week from the 9th month of pregnancy to the 45th postpartum day (except the week of childbirth), in order to collect their consumption data of the delivered food products. |
|
| food questionnaire | Other | Participants will have to complete a food questionnaire at the inclusion and at 21 days post-partum |
|
| newborn faeces sample | Other | Newborn faeces sample will be collected at 21 Days post partum |
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| breast milk sample | Other | Breast milk sample will be collected at 21 days and 45 days post partum |
|
| on the 21st and the 45th postpartum days |
| The cytokine content of breast milk | The cytokine content of breast milk on the 21st and the 45th postpartum days: IL-6, TNFα, TGFβ | on the 21st and the 45th postpartum days |
| The immunoglobulin A and G content of breast milk | The immunoglobulin A and G content of breast milk on the 21st and the 45th postpartum days; | on the 21st and the 45th postpartum days; |
| The lactoferrin content (antimicrobial factor) of breast milk | The lactoferrin content (antimicrobial factor) of breast milk on the 21st and the 45th postpartum days; | on the 21st and the 45th postpartum days; |
| The hormone content of breast milk | The hormone content of breast milk on the 21st and the 45th postpartum days: adiponectin, leptin, insulin; | on the 21st and the 45th postpartum days |
| The oligosaccharide content of breast milk | The oligosaccharide content of breast milk on the 21st and the 45th postpartum days; | on the 21st and the 45th postpartum days |
| The breast milk microbiota content | The breast milk microbiota content on the 21st and the 45th postpartum days; | on the 21st and the 45th postpartum days |
| the bacterial intestinal microbiota content from the feces of the newborn | the bacterial intestinal microbiota content from the feces of the newborn on the 21st postpartum day; | on the 21st postpartum day; |
| Fatty acid content | the fatty acid content of the women red blood cells of the woman before the 7th month of pregnancy and on the 21st postpartum day. | before the 7th month of pregnancy and on the 21st postpartum day. |
| The breast milk lipidome | the breast milk lipidome on the 21st postpartum day: 26 lipid classes comprising more than 300 different lipid species (in addition to the total fatty acid analyses of breast milk, in order to make a complete description of the lipid species provided); | on the 21st postpartum day |
| The maternal milk metabolome | the maternal milk metabolome on the 21st postpartum day: metabolites, hormones and other signal molecules (this analysis complements the previous ones by producing a complete description of non-lipid metabolites in breast milk); | On the 21st postpartum day |
| ID | Term |
|---|---|
| D001942 | Breast Feeding |
| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D015596 | Nutrition Assessment |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
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