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The purpose of this study prospective observational study is to determine cognitive dysfunction incidence after thoracic surgery. We also evaluate evaluate the role of cerebral oxygen desaturations and hypertension as risk factors for post-operative cognitive dysfunction (POCD) in patients undergoing lung resection.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cerebral desaturation monitoring and cognitive examination | Diagnostic Test | Before general anesthesia, continuous monitoring of cerebral oxygenation(rSO2) was started using an INVOS 5100 (Somaneic, Tro, MI) .Patient cognitive function was assessed using Mini-Mental State Examination (MMSE) on the day before surgery (baseline) and then after 1 day after surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of cognitive dysfunction after thoracic surgery | A decrease in Mini-Mental State Examination (MMSE) score > 2 points from baseline was defined as Postoperative cognitive dysfunction (POCD) | change of MMSE score from the day before surgery (baseline) at 1 day after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| role of cerebral oxygen desaturations as risk factors for POCD in patients undergoing lung resection. | monitoring values of cerebral saturation during intraoperative period:Cerebral desaturation was defined as a reduction of rSO2 during OLV of more than 20% from the baseline value | change of cerebral saturation from baseline(before surgery) at intraoperative measure |
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Inclusion Criteria:
Exclusion Criteria:
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patients scheduled for elective lobectomy or wedge resection via thoracotomy requiring an OLV duration ≥ 45 min
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| azienda ospedaliero universitaria Sant'Andrea | Roma | Italy |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| role of hypertension as risk factors for POCD in patients undergoing lung resection. | monitoring values of blood pressure during intraoperative period | change of blood pressure from baseline(before surgery) at intraoperative measure |