Selective Thromboembolism Prophylaxis After Arthroplasty

Selective Thromboembolism Prophylaxis After Total Hip Arthroplasty or Total Knee Arthroplasty by a Risk Stratification With Thromboelastography for Asian Populations: A Randomized Control Trial

Asian populations have a lower rate of high-risk gene mutations of venous thrombosis, which means a reasonable perioperative anticoagulant management after hip or knee arthroplasty for Caucasian populations may be too excessive for Asians. So, individual patient risk assessment, rather than a "blanket policy", is considered the best thromboembolism prophylaxis for Asians.The purpose of this study was to evaluate the effectiveness and safety of selective thromboembolism prophylaxis compared with conventional thromboembolism prophylaxis by risk stratification with thromboelastography (TEG) after joint arthroplasty for Asian populations.

Asian patients who underwent hip or knee arthroplasty in Guangdong General Hospital from August 2016 to August 2017 were randomly divided into selective anticoagulation group (SAG) and conventional anticoagulation group (CAG). SAG used anticoagulant when TEG indicated hypercoagulability while CAP used anticoagulant until one month after surgery regularly. Data including patients' basic information, postoperative complications, perioperative clotting index, intraoperative blood loss, perioperative TEG, volume of drainage, and blood transfusion were evaluated.

Inclusion Criteria:

• over 18 years of age,
• ASA Ⅰ-Ⅱ grade,
• BMI <40Kg / M ^ 2
• Underwent total knee arthroplasty/ total hip arthroplasty in Guangdong General Hospital
• consent to enroll in this study

Exclusion Criteria:

• history of VTE, preoperative infection, preoperative coagulation
• liver and kidney function existed clinically abnormalities
• history of tumor
• history of vascular surgery
• heart infarction or cerebral infarction within 6 months
• history of lower extremity surgery within 3 months