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| Name | Class |
|---|---|
| First Hospital of China Medical University | OTHER |
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Through multicenter, prospective, randomized, controlled clinical studies comparing different treatment options (fertility-sparing surgery and ovarian preservation surgery and radical surgery)therapeutic efficacy, safety and quality of life of patients, exploration of the best strategies and risks for the treatment of early endometrial cancer, and promotion and application.
Patients eligible for enrollment are selected and divided into three groups randomly, including fertility group,ovarian preservation group and endometrial cancer radical surgery group. Take interventions including fertility preservation surgery,ovarian preservation surgery and endometrial cancer radical surgery for patients in different groups respectively. Compare therapeutic efficacy, safety and quality of life of patients to evaluate three treatment and explore the best treatment for clinical application.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| radical surgery group | Experimental | Endometrial cancer radical surgery to be administered in this arm. |
|
| fertility preservation group | Experimental | Fertility-sparing surgery to be administered in this arm. |
|
| ovarian preservation group | Experimental | Ovarian preservation surgery to be administered in this arm. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endometrial cancer radical surgery | Procedure | Take hysterectomy and bilateral adnexectomy. |
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| Measure | Description | Time Frame |
|---|---|---|
| Total survival Time | calculate the time from patients enter the group to death | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| the change of Ovarian volume | measure the ovarian volume dynamically by ultrasonography | 6 months, 1 year, 2 years, 3 years, 4 years, 5 years |
| the change of endocrine function evaluation | measure the endocrine function(hormone level) dynamically by blood detection |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Min Wang, PHD. | Contact | 18940251222 | wm21st@126.com | |
| YiSi Liu | Contact | 18640138683 | liuyisi91@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Min Wang, PHD. | Shengjing Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shengjing Hospitaol of China Medical University | Shenyang | Liaoning | 110004 | China |
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| ID | Term |
|---|---|
| D016889 | Endometrial Neoplasms |
| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
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| fertility-sparing surgery | Procedure | Take endometrectomy , preserve uterus and bilateral ovaries. |
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| ovarian preservation surgery | Procedure | Take hysterectomy,preserve bilateral ovaries. |
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| 6 months, 1 year, 2 years, 3 years, 4 years, 5 years |
| Progression Free Survival | calculate the time from patients enter the group to tumor progression | 6 months |
| D009369 |
| Neoplasms |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |