The purpose of this study is to evaluate the efficacy and safety of GC1102 in combination of Nucleo(t)ide analogues (NAs) in patients with chronic hepatitis B

Inclusion Criteria:

• Patients who had this study information explained to them and understood it, voluntarily decided participation, and provided written consent
• Patients who Aged ≥19 and ≤ 65 years at the time of signing the consent form
• Patients with chronic hepatitis B who have been taking Nucleos(t)ide analogue antivirals 24 weeks before screening
• Patients whose HBsAg and HBV DNA in blood; 10 IU/mL ≤ HBsAg titer ≤ 1,000 IU/mL and negative(-; below the limit of detection of 10 IU/mL) HBV DNA in the screening test

Exclusion Criteria:

• Patients who have Hepatic diseases (e.g., autoimmune hepatitis) from causes other than hepatitis B
• Patients who have history of liver transplantation, or liver transplantation schedule during the study
• Patients who co-infected with HAV, HCV, HDV and HIV
• Patient with Vasculitis
• Patients who had a loss of blood or donated blood of ≥ 400mL within 8 weeks before the screening
• patient who have active infection(other than chronic hepatitis B infection) requiring continual treatment with antibiotics or antivirals (except for clinically insignificant temporary infection such as cold)