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The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-endurance group | Experimental | This group of subjects will receive 2-3 sessions of high-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will interchange between the aerobic and anaerobic state. |
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| Low-endurance group | Experimental | This group of subjects will receive 2-3 sessions of low-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will maintain at an aerobic level. |
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| Psycho-education | Active Comparator | This group of subjects will receive 2-3 sessions of psycho-education class per week, for a total of 12 weeks. The content of the class includes non-exercise related psycho-education content to participants (e.g., food hygiene, psychological well being, food nutrition, etc). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Other | Indoor cycling exercise intervention |
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| Measure | Description | Time Frame |
|---|---|---|
| The sleep-dependent procedural memory consolidation after 12 weeks of intervention | Tested by comparing the finger-tapping motor sequence task performance between the three groups during the 12-week follow-up assessment. | 12-week Follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| The verbal memory consolidation after 12 weeks of intervention | Tested by comparing the logical memory task performance between the three groups during the 12-week follow-up assessment | 12-week Follow-up |
| The attention performance after 12 weeks of intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lik Hang Lincoln Lo | The University of Hong Kong | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34615565 | Derived | Lo LLH, Lee EHM, Hui CLM, Chong CSY, Chang WC, Chan SKW, Lin JJ, Lo WTL, Chen EYH. Effect of high-endurance exercise intervention on sleep-dependent procedural memory consolidation in individuals with schizophrenia: a randomized controlled trial. Psychol Med. 2023 Apr;53(5):1708-1720. doi: 10.1017/S0033291721003196. Epub 2021 Oct 7. |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D011618 | Psychotic Disorders |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Non-exercise | Other | Psycho-education |
|
Measured by using the cancellation task performance and compare between the three groups during the 12-week follow-up assessment |
| 12-week Follow-up |
| The sleep quality after 12 weeks of intervention | Measured by using the Pittsburgh Sleep Quality Index (PSQI) and compare the differences between the three groups during the 12-week follow-up assessment | 12-week Follow-up |
| The insomnia severity after 12 weeks of intervention | Measured by using the Insomnia Severity Index (ISI) and compare the differences between the three groups during the 12-week follow-up assessment | 12-week Follow-up |