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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01HD084380 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
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DESCRT will be a long-term study that both looks back in time, at successful pregnancies, and forward in time at early pregnancy and long-term as these children grow. Currently, there are limited data on the long-term effects of infertility and infertility treatments on children. There are some studies to suggest that these children may have altered metabolic profiles, but this study aims to be the largest study to answer this question.
Over the past 30 years, much of the research and clinical effort in the field of ART had to do with improving outcome in terms of successful pregnancy. However, as these rates have increased, attention is slowly turning to focus on the health of the resultant child. Short-term health complications, in particular birth defects,have been well-described. However, even this "hard" outcome has been difficult to characterize as studies used different methodologies, varied age of detection, and frequently didn't have an appropriate comparison group. When underlying parental factors and infertility are included in the analyses, the association is substantially weakened or disappears completely. This exemplifies the problems with much of the currently available research regarding childhood outcomes following ART. While the health of children born through these technologies is of critical public health interest, and of personal interest to families, only limited data exist.
In order to evaluate the potential risk to long-term health of children conceived through assisted reproductive technologies (ART) and non-IVF fertility treatments (NIFT), rigorous epidemiological methods, appropriate characterization of the exposure, standardized collection of outcome data, and appropriate comparison groups are required. The proposed Developmental Epidemiological Study of Children born through Reproductive Technology (DESCRT) is aimed to carefully address these important characteristics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retrospective | Children born with assistance | ||
| Prospective | People who have sought evaluation/treatment for infertility |
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| Measure | Description | Time Frame |
|---|---|---|
| Metabolic testing of child - fasting glucose | Fasting glucose mg/dL | 1 day at study visit |
| Metabolic testing of child - fasting insulin | Fasting insulin uIU/mL | 1 day at study visit |
| Metabolic testing of child - uric acid | uric acid mg/dL | 1 day at study visit |
| Metabolic testing of child - total cholesterol | Cholesterol, Total mg/dL | 1 day at study visit |
| Metabolic testing of child - HDL cholesterol | HDL cholesterol mg/dL | 1 day at study visit |
| Metabolic testing of child - LDL cholesterol | LDL cholesterol mg/dL | 1 day at study visit |
| Metabolic testing of child - Triglycerides | Triglycerides mg/dL | 1 day at study visit |
| Metabolic testing of child - cholesterol ratio | CHOL/HDLC ratio | 1 day at study visit |
| Metabolic testing of child - non-HDL cholesterol |
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Retrospective arm
Inclusion criteria:
- children conceived by parent(s) who sought evaluation/treatment for infertility
Exclusion criteria:
- Children with chronic medical illnesses that prevent a study visit
Prospective arm
Inclusion criteria:
- seeking evaluation/treatment for infertility
Exclusion criteria:
- none
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Retrospective:
- children conceived by parent(s) who sought evaluation/treatment for infertility
Prospective:
- people seeking evaluation/treatment for infertility
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| Name | Affiliation | Role |
|---|---|---|
| Marcelle Cedars, MD | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, San Francisco | San Francisco | California | 94115 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42334867 | Derived | Huang D, Flynn E, Davidson BR, Irwin JC, Naser M, Almonte AL, Qin J, Song Y, Rabara FB, Wong R, Zablotska LB, Rosen MP, Wittmann T, Fragiadakis GK, Combes AJ, Sirota M, Cedars MI, Giudice LC. Programmed cycle-induced endometrial perturbations do not independently influence angiogenic imbalance or hypertensive disorders in pregnancy. JCI Insight. 2026 Jun 23:e202443. doi: 10.1172/jci.insight.202443. Online ahead of print. | |
| 37265937 | Derived |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| D007247 | Infertility, Female |
| D007248 | Infertility, Male |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
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Non-HDL cholesterol mg/dL |
| 1 day at study visit |
| Metabolic testing of child - Alanine Aminotransferase | Alanine Aminotransferase (ALT) U/L | 1 day at study visit |
| Adeleye AJ, Zablotska L, Rinaudo P, Huang D, Lustig RH, Cedars MI. Study protocol for a Developmental Epidemiological Study of Children born through Reproductive Technologies (DESCRT). Hum Reprod Open. 2023 May 5;2023(2):hoad013. doi: 10.1093/hropen/hoad013. eCollection 2023. |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D005832 | Genital Diseases, Male |
| D052801 | Male Urogenital Diseases |