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Heparanase is an endo-β-glucuronidase that cleaves heparin-sulfate (HS) side chains of heparan sulfate proteoglycans, an integral constituent of the extra cellular matrix (ECM).
This study aims to investigate the association between heparanase expression in the human placenta and preterm birth (PTB) .
The investigators hypothesize that an abnormal placentation causes relative placental ischemia that induces higher rates of heparanase expression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Elective term cesarean | Low-risk women undergoing elective term cesarean section |
| |
| Term vaginal delivery | Low-risk women undergoing term vaginal delivery |
| |
| Preterm vaginal delivery | Women undergoing preterm vaginal delivery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placental analysis | Other | Analysis of placenta to determine expression of heparanase |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heparanase expression | Heparanase expression in the human placenta following delivery will be evaluated by western blot analysis in the three groups and will be compared to determine differences in the levels. | Six months |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant women attending our obstetrical unit
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| Name | Affiliation | Role |
|---|---|---|
| Rinat Gabbay-Benziv, MD | Hillel Yaffe Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hille Yaffe Medical Center | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| D000091642 | Urogenital Diseases |