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Parkinson's disease is a progressive chronic neurodegenerative disease. In cases where drug treatment is insufficient and drug use is not possible due to drug side effects, highly effective and low-risk surgical treatment options could be used. In Parkinson's Disease; findings such as chest wall rigidity and weakness of the respiratory muscle strength occur. The aim of this study was to determine the effect of preop and postop DBS surgery on respiratory muscle strength, respiratory function and physical performance in patients with Parkinson's disease.
In the study, at least 10 patients with Parkinson's disease who had DBS surgery in Mustafa Kemal University Research and Practice Hospital, Department of Brain and Nerve Surgery will be evaluated. Demographic-physical features, pulmonary functions, respiratory muscle strength, exercise capacity, functionality, and muscle strength will be evaluated
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parkinson's Disease Group | Experimental | MIP and MEP Respiratory Function Test Strength Test |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MIP and MEP | Device | Pre-op, Post-op of, 1 month after surgery, 3 months after surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Functional exercise capacity | 6 minute walking test | Change from Baseline Functional exercise capacity at 3 months(Pre-op,Post-op Off, Post-op 1. month, Post-op 3. Month), an average of 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary functions | Spirometry | Change from Pulmonary functions at 3 months(Pre-op,Post-op Off, Post-op 1. month, Post-op 3. Month), an average of 3 months |
| Inspiratory and expiratory muscle strength (MIP, MEP) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Deran Oskay, PhD | Contact | 0312 2162600 | 2162627 | deranoskay@yahoo.com |
| Bircan Yucekaya, MSc | Contact | 03262455516 | 15514 | bircanyucekaya@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Deran Oskay, PhD | Gazi University Faculty of Health Science Department of Physical Therapy | Study Director |
| Bircan Yucekaya, MSc | Hatay Mustafa Kemal University School of Physical Therapy and Rehabilitation | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hatay Mustafa Kemal University | Recruiting | Antakya | Hatay | 30100 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17130410 | Background | Stemper B, Beric A, Welsch G, Haendl T, Sterio D, Hilz MJ. Deep brain stimulation improves orthostatic regulation of patients with Parkinson disease. Neurology. 2006 Nov 28;67(10):1781-5. doi: 10.1212/01.wnl.0000244416.30605.f1. | |
| 20022689 | Background | Trachani E, Constantoyannis C, Sirrou V, Kefalopoulou Z, Markaki E, Chroni E. Effects of subthalamic nucleus deep brain stimulation on sweating function in Parkinson's disease. Clin Neurol Neurosurg. 2010 Apr;112(3):213-7. doi: 10.1016/j.clineuro.2009.11.015. Epub 2009 Dec 22. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D012131 | Respiratory Insufficiency |
| D018908 | Muscle Weakness |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D000072277 | Maximal Respiratory Pressures |
| D012129 | Respiratory Function Tests |
| ID | Term |
|---|---|
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Mouth pressure device
| Change from Inspiratory and expiratory muscle strength (MIP, MEP) at 3 months(Pre-op,Post-op Off, Post-op 1. month, Post-op 3. Month), an average of 3 months |
| Muscle strength | Muscle Testing Device (N) | Change from Peripheral muscle strength at 3 months(Pre-op,Post-op Off, Post-op 1. month, Post-op 3. Month), an average of 3 months |
| Grip Test (Peripheral muscle strength) | Hand Held Dynamometer (kgf) | Change from Peripheral muscle strength at 3 months(Pre-op,Post-op Off, Post-op 1. month, Post-op 3. Month), an average of 3 months |
| Atilla Yılmaz, Med. Dr | Hatay Mustafa Kemal University Department of Neurosurgery | Principal Investigator |
| 21841525 | Background | Hyam JA, Brittain JS, Paterson DJ, Davies RJ, Aziz TZ, Green AL. Controlling the lungs via the brain: a novel neurosurgical method to improve lung function in humans. Neurosurgery. 2012 Feb;70(2):469-77; discussion 477-8. doi: 10.1227/NEU.0b013e318231d789. |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |