Threatened Preterm Birth and Time of Subsequent Delivery -a Prediction Model

Threatened Preterm Birth and Time of Subsequent Delivery; Prediction Model Based on Biomarkers and Maternal/Obstetrical Characteristics

This study investigates immunological and clinical markers in threatened preterm birth aiming to create a prediction model for preterm birth.

Preterm birth is the main cause of neonatal mortality and morbidity and despite a lot of effort the mechanisms leading to preterm birth are poorly understood. In threatened preterm birth it is difficult to identify the true high risk cases ultimately leading to preterm birth. These women are often overtreated.

In this study blood samples are taken from women with threatened preterm birth and from women with normal pregnancies before and during labor.

Differences in clinical characteristics and immunological markers between the groups are studied in order to design a prediction model for preterm birth.

Inclusion Criteria:

• Threatened preterm birth before 34 weeks of gestation; either threatened preterm labor and/or preterm prelabor rupture of the membranes
• Age > 18 years
• Swedish-speaking (understanding study information)

Exclusion Criteria:

• Multiple gestation
• Blood borne infections