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Frailty is the clinically recognizable medical condition, also called syndrome or phenotype, that is, the result of processes leading to an increased vulnerability for serious deteriorations in health and the diminished ability to cope with physical stressors. Recently, frailty has emerged as a significant risk factor for adverse postoperative outcomes. It is related to declines in energy, strength, and function as well as to an increased inflammatory state, including elevated levels of interleukin 6 (IL-6), C-reactive protein (CRP), and anelevated white blood cell count . Frailty, as defined Frailty, as defined in the landmark paper by Fried, included at least three of five of the following criteria: unintentional loss of weight, low physical activity, low energy, low grip strength, and a slowed walking speed. Since then, various frailty scoring lists have been designed to optimize the predictive value. One of these is the Edmonton Frail Scale (EFS), an instrument that can be assessed quickly, using only a simple questionnaire which usually does not require more than five minutes to be completed and which covers most domains of functioning, making it easy and fast to get a reliable impression of the degree of frailty.The aim of this study was to determine which factors,with emphasis on frailty, significantly influence postoperative outcome after elective noncardiac surgery as measured by the Comprehensive Complication Index (CCI).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| frailty | |||
| nonfrailty |
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| Measure | Description | Time Frame |
|---|---|---|
| one-year mortality | To investigate the one-year mortality of the frailty patients | 2019.02-2020.02 |
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Inclusion Criteria:
Exclusion Criteria:
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≥65 years
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiaoyun Sun, Master | Contact | 18752009886 | 977988901@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Gaojun Teng, PhD | Zhongda Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongda Hospital | Recruiting | Nanjing | Jiangsu | 210009 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40972266 | Derived | Shi JY, Gao DP, Chen R, Hu XY, Zhu LY, Zhang Y, Li Q, Mao QH, Ji MH, Fan D, Liu QR. Leveraging data-driven machine learning: From explainable risk prediction to hierarchical clustering-based subtypes of postoperative delirium in a prospective non-cardiac surgery cohort. J Clin Anesth. 2025 Nov;107:112006. doi: 10.1016/j.jclinane.2025.112006. Epub 2025 Sep 18. | |
| 35982410 |
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| Mao M, Wang LY, Zhu LY, Wang F, Ding Y, Tong JH, Sun J, Sun Q, Ji MH. Higher serum PGE2 is a predicative biomarker for postoperative delirium following elective orthopedic surgery in elderly patients. BMC Geriatr. 2022 Aug 19;22(1):685. doi: 10.1186/s12877-022-03367-y. |