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To investigate whether and how the CBM training will alleviate the symptoms of addiction in Internet gaming disorders.
The purpose of this study is to use the modification training of cognitive bias to ameliorate the severity and symptoms of Internet gaming disorders(IGD); the neural mechanisms of cognitive bias modification and its effect during cued-induced craving task in subjects with IGD will be investigated as well. This project will be conducted in Beijing, China.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CBM training | Experimental | participants have to complete the picture assessment task ; Approach-avoidance Task(AAT) and cue-induced task in the fMRIï¼›data on game-craving level, game hours, the ability of self-control and emotion regulation are also collected. Half of the participants will be random-assigned into the CBM training group; Each participant will do these task twice( e.g. Before training and after training) |
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| Sham training | Sham Comparator | participants have to complete the picture assessment task ; Approach-avoidance Task(AAT) and cue-induced task in the fMRIï¼›data on game-craving level, game hours, the ability of self-control and emotion regulation are also collected. Half of the participants will be random-assigned into the sham training group; Each participant will do these task twice( e.g. Before training and after training) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CBM training | Procedure | participants will be random-assigned into one of training groups. Participants in the modification group will receive modified training of 400 trials for six sessions during six days, the same as the sham group.The difference between these two groups is the proportion of push/pull trials. The sequence of the interventions will be counterbalanced across participants, and the callback will be conduct after one week. |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral outcome | Cognitive bias outside fMRI measured by AAT task takes the response times[[Push_game_pic-Pull_game_pic]-[Push_object_pic - Pull_object_pic])] as the index. The response times (cognitive bias scores) will be calculated under Repeated Measurement Anova by using SPSS software. | 60- 80 minutes after training |
| Resting-state functional connectivity alterations in brain. | Using seed-based and network level functional connectivity analysis, as well as graph theory analysis , functional connectivity in brain under eight minutes resting state will be detected and compared between CBM training group and sham group | 30-45 minutes after training |
| task-based fMRI brain activation | The active of the brain regions in mPFC and VS during AAT task changes after CBM training compared with the sham. There should be an decrease in ventral striatum and amygdala during the cue-induced task. These task-based fMRI data will be contrasted using SPM. | 45-60 minutes after training |
| Correlation analysis | The correlation between functional network organization in brain across resting state ( task-based fMRI) and cognitive bias scores will be explored. | 30- 60 minutes after training |
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Inclusion Criteria:
1, DSM-5 recommended diagnosis of Internet gaming disorder :
2, the scores of the Y-IAT(Young-Internet addiction Test) ≥ 50
Exclusion Criteria:
current or history of use of illegal substances and gambling;
current or history of psychiatric or neurological illness;
current use of psychotropic medications.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rui Wang, Master | Contact | +8618810315922 | 851006286@qq.com | |
| Jin-Tao Zhang, PhD | Contact | +8610 58800728 | zhangjintao@bnu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Jin-Tao Zhang, PhD | Beijing Normal University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University | Recruiting | Beijing | Beijing Municipality | 100875 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25526597 | Background | Wiers CE, Stelzel C, Gladwin TE, Park SQ, Pawelczack S, Gawron CK, Stuke H, Heinz A, Wiers RW, Rinck M, Lindenmeyer J, Walter H, Bermpohl F. Effects of cognitive bias modification training on neural alcohol cue reactivity in alcohol dependence. Am J Psychiatry. 2015 Apr;172(4):335-43. doi: 10.1176/appi.ajp.2014.13111495. Epub 2014 Dec 19. | |
| 25639749 |
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| ID | Term |
|---|---|
| D000082424 | Internet Addiction Disorder |
| ID | Term |
|---|---|
| D000088942 | Technology Addiction |
| D016739 | Behavior, Addictive |
| D003192 | Compulsive Behavior |
| D007175 | Impulsive Behavior |
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The investigators assigned subjects to two training groups and collected pre - and post-test data
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double blind: both participants and experimenters won't know which group is training group or sham control group.
|
| Sham training | Procedure | participants will be random-assigned into one of training groups. Participants in the modification group will receive modified training of 400 trials for six sessions during six days, the same as the sham group.The difference between these two groups is the proportion of push/pull trials. The sequence of the interventions will be counterbalanced across participants, and the callback will be conduct after one week. |
|
| Wiers CE, Ludwig VU, Gladwin TE, Park SQ, Heinz A, Wiers RW, Rinck M, Lindenmeyer J, Walter H, Bermpohl F. Effects of cognitive bias modification training on neural signatures of alcohol approach tendencies in male alcohol-dependent patients. Addict Biol. 2015 Sep;20(5):990-9. doi: 10.1111/adb.12221. Epub 2015 Jan 13. |
| 17126289 | Background | Rinck M, Becker ES. Approach and avoidance in fear of spiders. J Behav Ther Exp Psychiatry. 2007 Jun;38(2):105-20. doi: 10.1016/j.jbtep.2006.10.001. Epub 2006 Nov 28. |
| D001519 |
| Behavior |