Effects of Gum Arabic Supplementation in Hemodialysis Patients

Study of Some Pharmacological and Biochemical Effects of Gum Arabic Supplementation to Hemodilaysis Patients

Gum Arabic is a naturally produced gummy exudate from Acacia Senegal tree. It's a complex polysaccharide with proven prebiotic properties. Through its effect on intestinal bacteria, it's expected to reduce systemic levels of toxic bacterial metabolites and reduce inflammatory markers.By increasing fecal bacteria mass it's also expected to reduce blood urea level. These changes are potentially beneficial to hemodialysis patients who suffer from disturbed intestinal flora and a chronic inflammatory status. The investigators hypothesize that supplementing the diet of hemodialysis patients with Gum Arabic for four weeks would reduce inflammatory markers, increase total anti-oxidant capacity and reduce blood urea concentration.

Inclusion Criteria:

• Adult end-stage renal disease patients maintained on regular hemodialysis

Exclusion Criteria:

• Chronic liver disease
• Malignant condition
• Inflammatory bowel disease
• History of bowel resection
• Long term antibiotic therapy
• Pregnancy or lactation
• Current use of immunosuppressive medication