Postoperative headache is a major issue after general anaesthesia and surgery. The aim of this study is to investigate the possible difference in the occurrence of postoperative headache when general anaesthesia is maintained with propofol, which is supposed to have protective effects on migraine patients, versus sevoflurane.

Postoperative headache is a major issue after general anaesthesia and surgery. The aim of this study is to investigate the possible difference in the occurrence of postoperative headache when general anaesthesia is maintained with propofol, versus sevoflurane. Propofol acts throught a GABA, and is known to have a therapeutic effect on migraine patients with accute attacts. However, its role on postoperative headache has not been studied, when used for maintainance of anaesthesia, this study aims to investigate the occurrence of headache after anaesthesia and surgery, when patients receive randomly two different anaesthetics: propofol and sevoflurane.

Inclusion Criteria:

• ASA I-III
• scheduled operation under general anaesthesia
• operations <4 hours
• minorgynaecological operatios (leiomyomectomy)
• hernia repair
• arthroscopic procedurs
• minor orthopaedic operations without the use of tourniquet or cement
• saphenectomy
• minor urologic operations
• minor other operations of general surgery

Exclusion Criteria:

• age <18 and >65 years old
• ASA>III
• Diseases of the central nervous system (ie Parkinsons's disease, Multiple sclerosis, previous ischaemic attack, hydrocephalus, seizure disorder, etc)
• Psychosis under medication
• Cognitive impairement or/and inability to fill in the questionaires
• Allergy or contraindication to the study protocol included drugs
• Operations of more than 4 hours duration
• Head and neck procedures, procedures with neck extension (eg thyroidectomy), ENT procedures
• renal impairement
• hepatic impairement
• patient refusal

The patient and the outcomes assessor will not know what kind of anaesthetic drug was used for maintainance of anaesthesia.