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Strokes leads to significant morbidity and mortality, and hypertension is the most important risk factor for strokes. It is estimated that up to 10% of patients with hypertension have the underlying, treatable condition of primary aldosteronism. Hence, we hypothesize that the prevalence of primary aldosteronism is high in patients with strokes, a complication of long-standing hypertension.
Patients admitted with an acute stroke to the Acute Stroke Unit, Changi General Hospital, will be screened for Primary Aldosteronism three months post-stroke, and confirmatory tests will be done with saline-infusion test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single Arm | All patients admitted to the Acute Stroke Unit |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aldosterone renin ratio | Diagnostic Test | Aldosterone Renin Ratio to screen for Primary Aldosteronism |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patients with stroke with confirmed primary aldosteronism in patients admitted to the acute stroke unit for stroke | Percentage of patients with confirmed Primary Aldosteronism using confirmatory test | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Accuracy of Screening test in early period post-stroke | To determine if the screening blood test for primary aldosteronism performed within 1 week post-stroke is equally accurate compared to being performed 2-4 months post-stroke. | 3 months |
| Percentage of unilateral primary aldosteronism in patients admitted with acute stroke |
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Inclusion Criteria:
Exclusion Criteria:
a. Pregnant patients
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Prospective study to evaluate the prevalence of primary aldosteronism in patients with an acute stroke. 300 patients admitted with CVA/TIA will be enrolled into the study.
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| Name | Affiliation | Role |
|---|---|---|
| Troy Puar, MRCP UK | Changi General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Changi General Hospital | Singapore | 529889 | Singapore |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35518929 | Derived | Nguyen V, Tu TM, Mamauag MJB, Lai J, Saffari SE, Aw TC, Ong L, Foo RSY, Chai SC, Fones S, Zhang M, Puar TH. Primary Aldosteronism More Prevalent in Patients With Cardioembolic Stroke and Atrial Fibrillation. Front Endocrinol (Lausanne). 2022 Apr 19;13:869980. doi: 10.3389/fendo.2022.869980. eCollection 2022. |
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| ID | Term |
|---|---|
| D006929 | Hyperaldosteronism |
| D020521 | Stroke |
| D006973 | Hypertension |
| D001145 | Arrhythmias, Cardiac |
| ID | Term |
|---|---|
| D000308 | Adrenocortical Hyperfunction |
| D000307 | Adrenal Gland Diseases |
| D004700 | Endocrine System Diseases |
| D002561 | Cerebrovascular Disorders |
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Percentage of unilateral PA amongst patients with stroke |
| 6 months |
| Percentage of patients with positive screening test in patients admitted with acute stroke | 3 months |
| Blood pressure change after treatment for primary aldosteronism | 12 months |
| Cardiac Complications | Cardiac complications in patients with primary aldosteronism, compared to those without primary aldosteronism, as assessed by transthoracic echocardiography features of left ventricular hypertrophy / mass, and diastolic dysfunction | 6 months |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |